Childhood lead biokinetics and associations with age among a group of lead-poisoned children in China.
biomarkers
blood lead
bone lead
exposure assessment
toxicokinetics
Journal
Journal of exposure science & environmental epidemiology
ISSN: 1559-064X
Titre abrégé: J Expo Sci Environ Epidemiol
Pays: United States
ID NLM: 101262796
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
01
06
2017
accepted:
05
02
2018
revised:
18
01
2018
pubmed:
1
5
2018
medline:
6
5
2020
entrez:
1
5
2018
Statut:
ppublish
Résumé
Childhood lead exposure has been shown to have a significant effect on neurodevelopment. Many of the biokinetics involved with lead biomarkers in children still remain unknown. Two hundred fifty (157 in the exposed group and 93 controls) children were enrolled in our study and lead exposed children returned for multiple visits for measurement of blood and bone lead and chelation treatment. We demonstrated that the correlation between blood and bone lead increased with subsequent visits. We calculated the blood lead half-life for 50 patients, and found a significant (p-value < 0.001) positive correlation with age. For ages 1-3 years (N = 17), the blood lead half-life was found to be 6.9 ± 4.0 days and for 3+ years it was found to be (N = 33) 19.3 ± 14.1 days. In conclusion, the turnover of lead in children is faster than in adults. Our results indicate that blood lead is a more acute biomarker of exposure than previously thought, which will impact studies of children's health using blood lead as a biomarker.
Identifiants
pubmed: 29706621
doi: 10.1038/s41370-018-0036-y
pii: 10.1038/s41370-018-0036-y
pmc: PMC6207487
mid: NIHMS955691
doi:
Substances chimiques
Biomarkers
0
Lead
2P299V784P
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
416-423Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES000002
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES024700
Pays : United States
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