Dendritic Spine Elimination: Molecular Mechanisms and Implications.
dendritic spine
glutamate receptor
heterosynaptic plasticity
long-term depression
structural plasticity
synapse elimination
Journal
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
ISSN: 1089-4098
Titre abrégé: Neuroscientist
Pays: United States
ID NLM: 9504819
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
pubmed:
3
5
2018
medline:
18
6
2019
entrez:
3
5
2018
Statut:
ppublish
Résumé
Dynamic modification of synaptic connectivity in response to sensory experience is a vital step in the refinement of brain circuits as they are established during development and modified during learning. In addition to the well-established role for new spine growth and stabilization in the experience-dependent plasticity of neural circuits, dendritic spine elimination has been linked to improvements in learning, and dysregulation of spine elimination has been associated with intellectual disability and behavioral impairment. Proper brain function requires a tightly regulated balance between spine formation and spine elimination. Although most studies have focused on the mechanisms of spine formation, considerable progress has been made recently in delineating the neural activity patterns and downstream molecular mechanisms that drive dendritic spine elimination. Here, we review the current state of knowledge concerning the signaling pathways that drive dendritic spine shrinkage and elimination in the cerebral cortex and we discuss their implication in neuropsychiatric and neurodegenerative disease.
Identifiants
pubmed: 29716431
doi: 10.1177/1073858418769644
pmc: PMC6167191
mid: NIHMS971892
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
27-47Subventions
Organisme : NINDS NIH HHS
ID : R01 NS062736
Pays : United States
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