Dyslipidemia-associated atherogenic oxidized lipids induce platelet hyperactivity through phospholipase Cγ2-dependent reactive oxygen species generation.
OxLDL
PLCγ2
oxPC
platelet hyperactivity
reactive oxygen species
Journal
Platelets
ISSN: 1369-1635
Titre abrégé: Platelets
Pays: England
ID NLM: 9208117
Informations de publication
Date de publication:
2019
2019
Historique:
pubmed:
8
5
2018
medline:
14
5
2019
entrez:
8
5
2018
Statut:
ppublish
Résumé
Oxidized low-density lipoprotein (oxLDL) and associated oxidized phosphocholine-headgroup phospholipids (oxPCs) activate blood platelets through ligation of the scavenger receptor CD36. Previously, we found that oxLDL stimulated phosphorylation of phospholipase Cγ2 (PLCγ2). However, the functional relevance of PLCγ2 phosphorylation in oxLDL-mediated platelet hyperactivity remained elusive. Here, we set out to explore the functional importance of PLCγ2 in oxLDL-mediated platelet activation using human and genetically modified murine platelets. The CD36-specific oxidized phospholipid (oxPC
Identifiants
pubmed: 29733744
doi: 10.1080/09537104.2018.1466386
pmc: PMC6457275
doi:
Substances chimiques
Lipoproteins, LDL
0
Reactive Oxygen Species
0
oxidized low density lipoprotein
0
Phospholipase C gamma
EC 3.1.4.3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
467-472Subventions
Organisme : British Heart Foundation
ID : PG/11/37/28884
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/12/49/29441
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/13/90/30578
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/16/5/32250
Pays : United Kingdom
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