Natural History, Clinical Manifestations, and Pathogenesis of Hepatitis E Virus Genotype 1 and 2 Infections.
Acute Disease
Female
Genotype
Global Health
Hepatitis E
/ complications
Hepatitis E virus
/ genetics
Humans
Infant
Infant, Newborn
Infectious Disease Transmission, Vertical
Liver
/ pathology
Liver Failure, Acute
/ etiology
Nervous System Diseases
/ virology
Pregnancy
Pregnancy Complications, Infectious
/ epidemiology
Journal
Cold Spring Harbor perspectives in medicine
ISSN: 2157-1422
Titre abrégé: Cold Spring Harb Perspect Med
Pays: United States
ID NLM: 101571139
Informations de publication
Date de publication:
01 07 2019
01 07 2019
Historique:
pubmed:
8
5
2018
medline:
18
9
2020
entrez:
9
5
2018
Statut:
epublish
Résumé
Infection with genotype 1 or 2 hepatitis E virus (HEV) results primarily from human-to-human transmission through the fecal-oral route in low-resource countries. It presents primarily as "acute viral hepatitis" syndrome, usually a self-limiting illness. A few cases progress to acute liver failure, a serious illness with high fatality. Clinical disease is infrequent among children. Infection during pregnancy is associated with a higher risk of symptomatic disease, severe liver injury, and mortality. Severe disease is also encountered in persons with preexisting chronic liver disease. Some cases have associated extrahepatic features, particularly acute pancreatitis and neurological manifestations. Chronic infection appears to be extremely infrequent with these HEV genotypes. The exact pathogenesis of liver injury remains unknown, although the host immune response appears to be important for viral clearance as well as for induction of liver injury. Hormonal and immune factors appear to be responsible for the severe disease during pregnancy.
Identifiants
pubmed: 29735580
pii: cshperspect.a032136
doi: 10.1101/cshperspect.a032136
pmc: PMC6601454
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 Cold Spring Harbor Laboratory Press; all rights reserved.
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