Pathway perturbations in signaling networks: Linking genotype to phenotype.
Genetic mutations
Interactome and regulome
Network perturbations
Protein interactions
Signaling pathways
Journal
Seminars in cell & developmental biology
ISSN: 1096-3634
Titre abrégé: Semin Cell Dev Biol
Pays: England
ID NLM: 9607332
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
06
10
2017
revised:
29
03
2018
accepted:
04
05
2018
pubmed:
9
5
2018
medline:
12
3
2021
entrez:
9
5
2018
Statut:
ppublish
Résumé
Genes and gene products interact with each other to form signal transduction networks in the cell. The interactome networks are under intricate regulation in physiological conditions, but could go awry upon genome instability caused by genetic mutations. In the past decade with next-generation sequencing technologies, an increasing number of genomic mutations have been identified in a variety of disease patients and healthy individuals. As functional and systematic studies on these mutations leap forward, they begin to reveal insights into cellular homeostasis and disease mechanisms. In this review, we discuss recent advances in the field of network biology and signaling pathway perturbations upon genomic changes, and highlight the success of various omics datasets in unraveling genotype-to-phenotype relationships.
Identifiants
pubmed: 29738884
pii: S1084-9521(17)30528-1
doi: 10.1016/j.semcdb.2018.05.001
pmc: PMC6230320
mid: NIHMS1504092
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3-11Subventions
Organisme : NCI NIH HHS
ID : K22 CA214765
Pays : United States
Organisme : Medical Research Council
ID : MC_U105185859
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.
Références
Science. 2011 Aug 26;333(6046):1154-7
pubmed: 21798897
Cancer. 2009 Oct 1;115(19):4576-85
pubmed: 19551889
Mol Cancer Res. 2009 Jul;7(7):1110-8
pubmed: 19584259
Blood. 2005 Dec 1;106(12):3898-906
pubmed: 16118316
Mol Cell Biol. 2005 Jul;25(13):5363-79
pubmed: 15964794
Curr Opin Struct Biol. 2013 Jun;23(3):443-50
pubmed: 23706950
Pharmacol Ther. 2014 May;142(2):164-75
pubmed: 24333502
Nat Rev Cancer. 2007 Dec;7(12):937-48
pubmed: 18034184
Cell. 2015 Oct 22;163(3):712-23
pubmed: 26496610
J Exp Med. 2013 Feb 11;210(2):321-37
pubmed: 23359069
Science. 2004 Oct 8;306(5694):269-71
pubmed: 15472075
Cell. 2014 Nov 20;159(5):1212-1226
pubmed: 25416956
Nucleic Acids Res. 2015 Sep 30;43(17):8169-82
pubmed: 26304537
Mol Cancer Ther. 2016 Aug;15(8):1781-91
pubmed: 27413114
Dev Cell. 2010 Oct 19;19(4):491-505
pubmed: 20951342
Crit Rev Oncol Hematol. 2016 Mar;99:141-9
pubmed: 26775730
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Nucleic Acids Res. 2018 Feb 16;46(3):1113-1123
pubmed: 29325141
J Natl Cancer Inst. 2014 Jan;106(1):djt356
pubmed: 24309006
Nucleic Acids Res. 2016 Jun 2;44(10):4487-503
pubmed: 27105842
Mol Cell. 2016 Aug 18;63(4):579-592
pubmed: 27540857
J Exp Med. 2011 Jul 4;208(7):1389-401
pubmed: 21670202
DNA Repair (Amst). 2004 Aug-Sep;3(8-9):855-61
pubmed: 15279770
J Clin Oncol. 2015 Jun 10;33(17):1974-82
pubmed: 25605845
Nat Rev Mol Cell Biol. 2002 May;3(5):317-27
pubmed: 11988766
Cancer Discov. 2014 Dec;4(12):1418-29
pubmed: 25252692
Trends Biochem Sci. 2017 May;42(5):342-354
pubmed: 28284537
BMC Genomics. 2015;16 Suppl 8:S3
pubmed: 26110593
Nucleic Acids Res. 2013 Dec;41(22):e203
pubmed: 24194606
Clin Cancer Res. 2008 Aug 1;14(15):4989-94
pubmed: 18676774
Science. 2013 Mar 29;339(6127):1546-58
pubmed: 23539594
Mol Syst Biol. 2009;5:321
pubmed: 19888216
Cell. 1991 Aug 23;66(4):649-61
pubmed: 1831692
Mol Cell. 2012 Jun 29;46(6):871-83
pubmed: 22749400
Cancer Res. 2016 Oct 1;76(19):5587-5589
pubmed: 27698186
Oncogene. 2007 May 14;26(22):3291-310
pubmed: 17496923
Endocr Relat Cancer. 2017 Jul;24(7):X1
pubmed: 28566432
Nat Methods. 2015 Jul;12(7):615-621
pubmed: 26125594
Nat Rev Genet. 2013 Oct;14(10):703-18
pubmed: 24022702
Cell. 2015 Jul 16;162(2):425-440
pubmed: 26186194
BMC Genomics. 2006 Dec 05;7:306
pubmed: 17144929
Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7155-60
pubmed: 19369211
Nature. 2010 Apr 15;464(7291):993-8
pubmed: 20393554
Cell. 2011 Apr 1;145(1):30-8
pubmed: 21458666
Oncogene. 2007 May 14;26(22):3279-90
pubmed: 17496922
Cell. 2015 Apr 23;161(3):647-660
pubmed: 25910212
Nature. 2002 Jun 27;417(6892):949-54
pubmed: 12068308
Genes Dev. 2000 Apr 15;14(8):895-900
pubmed: 10783161
Am J Hum Genet. 2009 May;84(5):605-16
pubmed: 19409520
Nat Med. 2013 Nov;19(11):1410-22
pubmed: 24202394
Cell. 2011 Mar 18;144(6):986-98
pubmed: 21414488
Clin Genet. 2012 Aug;82(2):105-14
pubmed: 22356477
Mol Cell. 2005 Dec 22;20(6):963-9
pubmed: 16364920
Nature. 2012 Sep 6;489(7414):57-74
pubmed: 22955616
Nat Rev Clin Oncol. 2015 Aug;12(8):445-64
pubmed: 25850553
EMBO J. 2003 Oct 15;22(20):5612-21
pubmed: 14532133
Nucleic Acids Res. 2017 Jul 7;45(12):7094-7105
pubmed: 28549153
Nature. 2015 Sep 17;525(7569):339-44
pubmed: 26344197
Oncogene. 2014 Nov 13;33(46):5311-8
pubmed: 24336324
Nucleic Acids Res. 2011 Feb;39(3):825-36
pubmed: 20929877
Adv Exp Med Biol. 2009;656:85-106
pubmed: 19928355
Sci Rep. 2016 Dec 06;6:38588
pubmed: 27922122
Nucleic Acids Res. 2016 Jan 4;44(D1):D1005-10
pubmed: 26578591
Cell. 2004 Mar 19;116(6):855-67
pubmed: 15035987
Nat Methods. 2018 Jan;15(1):61-66
pubmed: 29200198
Nucleic Acids Res. 2017 Jan 4;45(D1):D896-D901
pubmed: 27899670
Sci Rep. 2016 May 09;6:25722
pubmed: 27158037
Cancer Lett. 2015 Dec 1;369(1):20-7
pubmed: 26341688
Genes Cancer. 2011 Mar;2(3):344-58
pubmed: 21779504
Nat Genet. 2015 Jul;47(7):710-6
pubmed: 26053494
Oncologist. 2015 Oct;20(10):1189-98
pubmed: 26306903
Oncol Lett. 2014 Sep;8(3):1249-1254
pubmed: 25120700
Stat Appl Genet Mol Biol. 2005;4:Article17
pubmed: 16646834
Ann Med. 2014 Sep;46(6):372-83
pubmed: 24897931
Nat Rev Cancer. 2005 Sep;5(9):689-98
pubmed: 16110319
Hum Pathol. 2008 Nov;39(11):1582-9
pubmed: 18703216
Nat Genet. 2013 Oct;45(10):1113-20
pubmed: 24071849
Annu Rev Pathol. 2009;4:461-87
pubmed: 18954285
Genome Biol. 2010;11(5):R53
pubmed: 20482850
Nat Genet. 2016 Nov;48(11):1321-1326
pubmed: 27723759
Mol Cell. 2010 Oct 22;40(2):179-204
pubmed: 20965415
Science. 2015 Feb 20;347(6224):1257601
pubmed: 25700523
Nucleic Acids Res. 2017 Jan 4;45(D1):D427-D431
pubmed: 27899616
Cell. 1999 Dec 10;99(6):577-87
pubmed: 10612394
Int J Immunogenet. 2015 Apr;42(2):93-9
pubmed: 25689638
Nature. 2017 Jan 18;541(7637):321-330
pubmed: 28102259
Nature. 2015 Nov 19;527(7578):384-8
pubmed: 26550823
Sci Transl Med. 2011 Aug 31;3(98):98ra82
pubmed: 21885404
Nucleic Acids Res. 2016 Nov 2;44(19):9438-9451
pubmed: 27365046
Cancer Res. 2005 Nov 1;65(21):9719-26
pubmed: 16266992
Nat Rev Cancer. 2015 Jun;15(6):321-33
pubmed: 25998712
Gut. 2007 Mar;56(3):417-25
pubmed: 16840506
Int J Clin Exp Pathol. 2015 Nov 01;8(11):15118-22
pubmed: 26823853
PLoS One. 2014 Oct 14;9(10):e108747
pubmed: 25314575
Curr Probl Cancer. 2011 Jan-Feb;35(1):7-50
pubmed: 21300207
Cancer. 2014 Nov 15;120(22):3446-56
pubmed: 24948110
Cell. 2017 Feb 9;168(4):600-612
pubmed: 28187283
J Exp Med. 2012 Aug 27;209(9):1553-65
pubmed: 22891276
Cancer Prev Res (Phila). 2015 Apr;8(4):259-61
pubmed: 25712049
Cold Spring Harb Perspect Biol. 2012 May 01;4(5):
pubmed: 22438566
Cell. 2009 Mar 20;136(6):1032-43
pubmed: 19303847
Cell. 2006 Jun 30;125(7):1253-67
pubmed: 16814713
Nature. 2017 May 25;545(7655):505-509
pubmed: 28514442
Cell. 2015 Apr 23;161(3):661-673
pubmed: 25910213
Nat Rev Cancer. 2013 Apr;13(4):246-57
pubmed: 23467301
Genes Chromosomes Cancer. 2011 Aug;50(8):644-53
pubmed: 21584898
Hum Genet. 2014 Jan;133(1):1-9
pubmed: 24077912
Hum Genet. 2017 Sep;136(9):1193-1214
pubmed: 28762175
Methods Mol Biol. 2011;759:197-213
pubmed: 21863489