Successful Brincidofovir Treatment of Metagenomics-detected Adenovirus Infection in a Severely Ill Signal Transducer and Activator of Transcription-1-deficient Patient.
Adenoviridae Infections
/ diagnosis
Antiviral Agents
/ therapeutic use
Cytosine
/ analogs & derivatives
Humans
Immunocompromised Host
Liver
/ immunology
Male
Metagenomics
Organophosphonates
/ therapeutic use
Osteomyelitis
/ drug therapy
STAT1 Transcription Factor
/ deficiency
Treatment Outcome
Young Adult
Journal
The Pediatric infectious disease journal
ISSN: 1532-0987
Titre abrégé: Pediatr Infect Dis J
Pays: United States
ID NLM: 8701858
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
pubmed:
10
5
2018
medline:
14
3
2020
entrez:
10
5
2018
Statut:
ppublish
Résumé
A signal transducer and activator of transcription-1-deficient patient presented with prolonged fever, cachexia, anemia, hypoalbuminemia and finally relapsing debilitating mycobacterial osteomyelitis while receiving a previously effective antimycobacterial treatment. Progression despite rigorous workup and multiple antibiotics prompted shotgun metagenomics revealing adenovirus in liver samples. Brincidofovir led to a complete, sustained clinical recovery, including osteomyelitis, probably attributed to reversal of adenovirus-induced immune dysregulation.
Identifiants
pubmed: 29742642
doi: 10.1097/INF.0000000000002090
doi:
Substances chimiques
Antiviral Agents
0
Organophosphonates
0
STAT1 Transcription Factor
0
STAT1 protein, human
0
brincidofovir
6794O900AX
Cytosine
8J337D1HZY
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM