Development, activation, and therapeutic potential of thermogenic adipocytes.
Beige fat
Brown fat
Human fat
Obesity
Thermogenesis
Journal
Biochimica et biophysica acta. Molecular and cell biology of lipids
ISSN: 1879-2618
Titre abrégé: Biochim Biophys Acta Mol Cell Biol Lipids
Pays: Netherlands
ID NLM: 101731727
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
03
11
2017
revised:
23
02
2018
accepted:
10
05
2018
pubmed:
16
5
2018
medline:
28
7
2019
entrez:
16
5
2018
Statut:
ppublish
Résumé
During the last decade, significant progress has been made in understanding adipocytes with a particular focus on thermogenic fat cells, which effectively convert chemical energy into heat in addition to their other metabolic functions. It has been increasingly recognized that different types and subtypes of adipocytes exist and the developmental origins of various types of fat cells are being intensively investigated. Previous work using immortalized fat cell lines has established an intricate transcriptional network that regulates adipocyte function. Recent work has illustrated how these key transcriptional components mediate thermogenic activation in fat cells. Last but not least, cumulative evidence supports an incontestable role of thermogenic fat in influencing systemic metabolism in humans. Here we summarize the exciting advancements in our understanding of thermogenic fat, discuss the advantages and limitations of the experimental tools currently available, and explore the future directions of this fast-evolving field.
Identifiants
pubmed: 29763732
pii: S1388-1981(18)30096-9
doi: 10.1016/j.bbalip.2018.05.004
pmc: PMC6240366
mid: NIHMS967958
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Pagination
13-19Subventions
Organisme : NIDDK NIH HHS
ID : F31 DK112625
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020572
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK107583
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.
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