Tailoring the homing capacity of human Tregs for directed migration to sites of Th1-inflammation or intestinal regions.

Animals Cell Adhesion Cell Movement Cell Proliferation Chemokine CXCL10 / metabolism Epigenesis, Genetic Female Humans Immune Tolerance Immunosuppression Therapy Inflammation / immunology Integrins / metabolism Interleukin-12 / immunology Intestines / immunology Male Mice Phenotype Receptors, CCR / metabolism Receptors, CXCR3 / metabolism T-Lymphocytes, Regulatory / cytology Th1 Cells / cytology Thymus Gland / immunology
basic (laboratory) research/science cellular biology cellular transplantation (non-islet) chemokines/chemokine receptors immune regulation immunosuppression/immune modulation intestinal (allograft) function/dysfunction lymphocyte biology: trafficking tolerance translational research/science

Journal

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638

Informations de publication

Date de publication:
01 2019
Historique:
received: 26 09 2017
revised: 17 04 2018
accepted: 06 05 2018
pubmed: 17 5 2018
medline: 17 4 2020
entrez: 17 5 2018
Statut: ppublish

Résumé

Cell-based therapy with CD4

Identifiants

DOI: 10.1111/ajt.14936 PMID: 29766641
pubmed: 29766641
doi: 10.1111/ajt.14936
pii: S1600-6135(22)08899-2
doi:

Substances chimiques

CC chemokine receptor 9 0
CXCL10 protein, human 0
CXCR3 protein, human 0
Chemokine CXCL10 0
Cxcl10 protein, mouse 0
Cxcr3 protein, mouse 0
Integrins 0
Receptors, CCR 0
Receptors, CXCR3 0
integrin alpha4beta7 0
Interleukin-12 187348-17-0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

62-76

Subventions

Organisme : CIHR
ID : MOP137033
Pays : Canada
Organisme : CIHR
ID : MOP93793
Pays : Canada
Organisme : CIHR
ID : ,TFU 127880
Pays : Canada
Organisme : CIHR
ID : FDN-154304
Pays : Canada

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2018 The American Society of Transplantation and the American Society of Transplant Surgeons.

Auteurs

R E Hoeppli (RE)

Department of Surgery, University of British Columbia & British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.

K N MacDonald (KN)

School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada.
Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.

P Leclair (P)

Department of Pediatrics, University of British Columbia & British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.

V C W Fung (VCW)

Department of Surgery, University of British Columbia & British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.

M Mojibian (M)

Department of Surgery, University of British Columbia & British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.

J Gillies (J)

Department of Surgery, University of British Columbia & British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.

S M R Rahavi (SMR)

Department of Pediatrics, University of British Columbia & British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.

A I M Campbell (AIM)

Department of Surgery, University of British Columbia & British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.

S K Gandhi (SK)

Department of Surgery, University of British Columbia & British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.

A M Pesenacker (AM)

Department of Surgery, University of British Columbia & British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.

G Reid (G)

Department of Pediatrics, University of British Columbia & British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.

C J Lim (CJ)

Department of Pediatrics, University of British Columbia & British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.

M K Levings (MK)

Department of Surgery, University of British Columbia & British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.
School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Tailoring the homing capacity of human Tregs...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Adhérence cellulaire › Tailoring the homing capacity of human Tregs...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Tailoring the homing capacity of human Tregs...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Tailoring the homing capacity of human Tregs...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Chimiokines › Chimiokines CXC › Chimiokine CXCL10 › Tailoring the homing capacity of human Tregs...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Tailoring the homing capacity of human Tregs...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Tailoring the homing capacity of human Tregs...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunomodulation › Tolérance immunitaire › Tailoring the homing capacity of human Tregs...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunosuppression thérapeutique › Tailoring the homing capacity of human Tregs...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Tailoring the homing capacity of human Tregs...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Intégrines › Tailoring the homing capacity of human Tregs...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-12 › Tailoring the homing capacity of human Tregs...
questionsmedicales.fr › Système digestif › Tube digestif › Intestins › Tailoring the homing capacity of human Tregs...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Tailoring the homing capacity of human Tregs...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Tailoring the homing capacity of human Tregs...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux chimiokines › Récepteurs CCR › Tailoring the homing capacity of human Tregs...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux chimiokines › Récepteurs CXCR › Récepteurs CXCR3 › Tailoring the homing capacity of human Tregs...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Tailoring the homing capacity of human Tregs...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Lymphocytes auxiliaires Th1 › Tailoring the homing capacity of human Tregs...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Thymus (glande) › Tailoring the homing capacity of human Tregs...