Interleukin-1 Receptor 1 Deletion in Focal and Diffuse Experimental Traumatic Brain Injury in Mice.
controlled cortical impact
interleukin-1
mice
traumatic brain injury
Journal
Journal of neurotrauma
ISSN: 1557-9042
Titre abrégé: J Neurotrauma
Pays: United States
ID NLM: 8811626
Informations de publication
Date de publication:
15 01 2019
15 01 2019
Historique:
pubmed:
18
5
2018
medline:
31
3
2020
entrez:
18
5
2018
Statut:
ppublish
Résumé
Important differences in the biology of focal and diffuse traumatic brain injury (TBI) subtypes may result in unique pathophysiological responses to shared molecular mechanisms. Interleukin-1 (IL-1) signaling has been tested as a potential therapeutic target in preclinical models of cerebral contusion and diffuse TBI, and in a phase II clinical trial, but no published studies have examined IL-1 signaling in an impact/acceleration closed head injury (CHI) model. We hypothesized that genetic deletion of IL-1 receptor-1 (IL-1R1 KO) would be beneficial in focal (contusion) and CHI in mice. Wild type and IL-1R1 KO mice were subjected to controlled cortical impact (CCI), or to CHI. CCI produced brain leukocyte infiltration, HMGB1 translocation and release, edema, cell death, and cognitive deficits. CHI induced peak rotational acceleration of 9.7 × 10
Identifiants
pubmed: 29768967
doi: 10.1089/neu.2018.5659
pmc: PMC6338578
doi:
Substances chimiques
Receptors, Interleukin-1
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
370-379Subventions
Organisme : NINDS NIH HHS
ID : R01 NS091573
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS092847
Pays : United States
Organisme : NICHD NIH HHS
ID : R21 HD086385
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG051506
Pays : United States
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