NADPH ameliorates MPTP-induced dopaminergic neurodegeneration through inhibiting p38MAPK activation.
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Animals
Apoptosis
/ drug effects
Cell Line, Tumor
Dopaminergic Neurons
/ drug effects
Glutathione
/ metabolism
Male
Mice
Mice, Inbred C57BL
NADP
/ therapeutic use
Neuroprotective Agents
/ therapeutic use
Parkinson Disease, Secondary
/ chemically induced
Reactive Oxygen Species
/ metabolism
p38 Mitogen-Activated Protein Kinases
/ antagonists & inhibitors
MPTP
NADPH
P-p38MAPK
PD
ROS
TP53
Journal
Acta pharmacologica Sinica
ISSN: 1745-7254
Titre abrégé: Acta Pharmacol Sin
Pays: United States
ID NLM: 100956087
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
25
08
2017
accepted:
15
01
2018
revised:
15
01
2018
pubmed:
18
5
2018
medline:
4
4
2019
entrez:
18
5
2018
Statut:
ppublish
Résumé
Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by the selective loss of dopaminergic neurons in substantia nigra pars compacta (SNpc). Although the pathogenic mechanism underlying PD remains largely unknown, decreased nigral glutathione (GSH) in postmortem brains of PD patients supports the presence of oxidative stress in PD. We found that Nicotinamide adenine dinucleotide phosphate (NADPH), which is important for maintaining the level of GSH, protected dopaminergic (DA) neurons from neurotoxicity of MPTP/MPP
Identifiants
pubmed: 29769744
doi: 10.1038/s41401-018-0003-0
pii: 10.1038/s41401-018-0003-0
pmc: PMC6329815
doi:
Substances chimiques
Neuroprotective Agents
0
Reactive Oxygen Species
0
NADP
53-59-8
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
9P21XSP91P
p38 Mitogen-Activated Protein Kinases
EC 2.7.11.24
Glutathione
GAN16C9B8O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
180-191Références
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