IgG1

Anaphylaxis / immunology Animals B-Lymphocytes / immunology Food Hypersensitivity / immunology Humans Immunity, Humoral Immunoglobulin E / immunology Immunoglobulin G / immunology Skin / pathology Time Factors
IgE-mediated food allergy IgG1+ memory B cells Th2 immunity anaphylaxis epicutaneous sensitization

Journal

Allergy
ISSN: 1398-9995
Titre abrégé: Allergy
Pays: Denmark
ID NLM: 7804028

Informations de publication

Date de publication:
01 2019
Historique:
accepted: 14 05 2018
pubmed: 24 5 2018
medline: 21 3 2020
entrez: 24 5 2018
Statut: ppublish

Résumé

The generation of IgE-mediated food allergy in humans is silent and only diagnosed upon manifestation of clinical symptoms. While experimental models have been used to investigate some mechanisms of allergic sensitization, the generation of humoral immunity and memory remains to be elucidated. Here, we defined the evolution of allergen-specific B-cell responses during epicutaneous sensitization to foods. Wild-type and genetic knockout animals, and drug or antibody strategies for cell depletion and immunoglobulin signaling blockade were used to investigate epicutaneous sensitization and disease progression; we analyzed allergen-specific germinal centers and IgG1 Epicutaneous sensitization caused microscopic skin damage, inflammation, and recruitment of activated dendritic cells to the draining lymph nodes. This process generated allergen-specific IgG1 Our data demonstrate that IgG1

Sections du résumé

BACKGROUND
The generation of IgE-mediated food allergy in humans is silent and only diagnosed upon manifestation of clinical symptoms. While experimental models have been used to investigate some mechanisms of allergic sensitization, the generation of humoral immunity and memory remains to be elucidated. Here, we defined the evolution of allergen-specific B-cell responses during epicutaneous sensitization to foods.
METHODS
Wild-type and genetic knockout animals, and drug or antibody strategies for cell depletion and immunoglobulin signaling blockade were used to investigate epicutaneous sensitization and disease progression; we analyzed allergen-specific germinal centers and IgG1
RESULTS
Epicutaneous sensitization caused microscopic skin damage, inflammation, and recruitment of activated dendritic cells to the draining lymph nodes. This process generated allergen-specific IgG1
CONCLUSIONS
Our data demonstrate that IgG1

Identifiants

DOI: 10.1111/all.13481 PMID: 29790165
pubmed: 29790165
doi: 10.1111/all.13481
doi:

Substances chimiques

Immunoglobulin G 0
Immunoglobulin E 37341-29-0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

165-175

Subventions

Organisme : Walter and Maria Schroeder Foundation
Pays : International
Organisme : AllerGen
Pays : International
Organisme : MedImmune LLC
Pays : International
Organisme : The Zych family
Pays : International
Organisme : The Delaney Family
Pays : International
Organisme : Food Allergy Canada
Pays : International

Informations de copyright

© 2018 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.

Auteurs

R Jiménez-Saiz (R)

Department of Pathology & Molecular Medicine, McMaster Immunology Research Centre (MIRC), McMaster University, Hamilton, ON, Canada.
ORCID: 0000-0002-0606-3251

Y Ellenbogen (Y)

Department of Pathology & Molecular Medicine, McMaster Immunology Research Centre (MIRC), McMaster University, Hamilton, ON, Canada.

J F E Koenig (JFE)

Department of Pathology & Molecular Medicine, McMaster Immunology Research Centre (MIRC), McMaster University, Hamilton, ON, Canada.

M E Gordon (ME)

Department of Pathology & Molecular Medicine, McMaster Immunology Research Centre (MIRC), McMaster University, Hamilton, ON, Canada.

T D Walker (TD)

Department of Pathology & Molecular Medicine, McMaster Immunology Research Centre (MIRC), McMaster University, Hamilton, ON, Canada.

D Rosace (D)

Department of Pathology & Molecular Medicine, McMaster Immunology Research Centre (MIRC), McMaster University, Hamilton, ON, Canada.

P Spill (P)

Department of Pathology & Molecular Medicine, McMaster Immunology Research Centre (MIRC), McMaster University, Hamilton, ON, Canada.

K Bruton (K)

Department of Pathology & Molecular Medicine, McMaster Immunology Research Centre (MIRC), McMaster University, Hamilton, ON, Canada.

J Kong (J)

Department of Pathology & Molecular Medicine, McMaster Immunology Research Centre (MIRC), McMaster University, Hamilton, ON, Canada.

K Monteiro (K)

Department of Pathology & Molecular Medicine, McMaster Immunology Research Centre (MIRC), McMaster University, Hamilton, ON, Canada.

J Wen (J)

Department of Pathology & Molecular Medicine, McMaster Immunology Research Centre (MIRC), McMaster University, Hamilton, ON, Canada.

E I Tuomanen (EI)

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.

R Kolbeck (R)

Department of Respiratory, Inflammation & Autoimmunity, MedImmune LLC, Gaithersburg, MA, USA.

D K Chu (DK)

Department of Medicine, McMaster University, Hamilton, ON, Canada.

S Waserman (S)

Department of Medicine, McMaster University, Hamilton, ON, Canada.

M Jordana (M)

Department of Pathology & Molecular Medicine, McMaster Immunology Research Centre (MIRC), McMaster University, Hamilton, ON, Canada.

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Classifications MeSH

questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Anaphylaxie › IgG1
questionsmedicales.fr › Eucaryotes › Animaux › IgG1
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › IgG1
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Hypersensibilité alimentaire › IgG1
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › IgG1
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Immunité humorale › IgG1
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline E › IgG1
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline G › IgG1
questionsmedicales.fr › Système tégumentaire › Peau › IgG1
questionsmedicales.fr › Phénomènes physiques › Temps › Facteurs temps › IgG1