Elevated histone H3 acetylation is associated with genes involved in T lymphocyte activation and glutamate decarboxylase antibody production in patients with type 1 diabetes.
CD4+ T lymphocytes
Histone H3 acetylation profile
Type 1 diabetes
Journal
Journal of diabetes investigation
ISSN: 2040-1124
Titre abrégé: J Diabetes Investig
Pays: Japan
ID NLM: 101520702
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
12
02
2018
revised:
16
05
2018
accepted:
18
05
2018
pubmed:
24
5
2018
medline:
15
2
2019
entrez:
24
5
2018
Statut:
ppublish
Résumé
Genetic and epigenetic mechanisms have been implicated in the pathogenesis of type 1 diabetes, and histone acetylation is an epigenetic modification pattern that activates gene transcription. However, the genome-wide histone H3 acetylation in new-onset type 1 diabetes patients has not been well described. Accordingly, we aimed to unveil the genome-wide promoter acetylation profile in CD4 A total of 12 patients with new-onset type 1 diabetes who were glutamate decarboxylase antibody-positive were enrolled, and 12 healthy individuals were recruited as controls. The global histone H3 acetylation level of CD4 Elevated global histone H3 acetylation level was observed in type 1 diabetes patients, with 607 differentially acetylated genes identified between type 1 diabetes patients and controls by chromatin immunoprecipitation linked to microarrays. The hyperacetylated genes were enriched in biological processes involved in immune cell activation and inflammatory response. Gene-specific assessments showed that increased transcription of inducible T-cell costimulator was in concordance with the elevated acetylation in its gene promoter, along with positive correlation with glutamate decarboxylase antibody titer in type 1 diabetes patients. The present study generates a genome-wide histone acetylation profile specific to CD4
Identifiants
pubmed: 29791073
doi: 10.1111/jdi.12867
pmc: PMC6319479
doi:
Substances chimiques
Antibodies
0
Histones
0
Glutamate Decarboxylase
EC 4.1.1.15
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
51-61Subventions
Organisme : National Science and Technology Infrastructure Program
ID : 2015BAI12B13
Organisme : National Natural Science Foundation of China
ID : 81461168031
Organisme : National Natural Science Foundation of China
ID : 81200580
Organisme : Key Project of Chinese Ministry of Education
ID : 113050A
Organisme : the Doctoral Fund of Ministry of Education of China
ID : 20120162120090
Organisme : Hunan Provincial Natural Science Foundation of China
ID : 14JJ3042
Organisme : Fundamental Research Funds for the Central Universities of Central South University
ID : 502221703
Organisme : China Scholarship Council
ID : 201606375127
Informations de copyright
© 2018 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
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