CGRP Receptor Biology: Is There More Than One Receptor?
AMY1
CGRP
CGRP receptor
Migraine
RAMP1
Journal
Handbook of experimental pharmacology
ISSN: 0171-2004
Titre abrégé: Handb Exp Pharmacol
Pays: Germany
ID NLM: 7902231
Informations de publication
Date de publication:
2019
2019
Historique:
pubmed:
26
5
2018
medline:
17
9
2019
entrez:
26
5
2018
Statut:
ppublish
Résumé
Calcitonin gene-related peptide (CGRP) has many reported pharmacological actions. Can a single receptor explain all of these? This chapter outlines the molecular nature of reported CGRP binding proteins and their pharmacology. Consideration of whether CGRP has only one or has more receptors is important because of the key role that this peptide plays in migraine. It is widely thought that the calcitonin receptor-like receptor together with receptor activity-modifying protein 1 (RAMP1) is the only relevant receptor for CGRP. However, some closely related receptors also have high affinity for CGRP and it is still plausible that these play a role in CGRP biology, and in migraine. The calcitonin receptor/RAMP1 complex, which is currently called the AMY
Identifiants
pubmed: 29797087
doi: 10.1007/164_2018_131
doi:
Substances chimiques
Calcitonin Receptor-Like Protein
0
Receptors, Calcitonin Gene-Related Peptide
0
Calcitonin
9007-12-9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM