Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma initiation in mice.
pancreatic cancer
pancreatitis
Journal
Gut
ISSN: 1468-3288
Titre abrégé: Gut
Pays: England
ID NLM: 2985108R
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
10
10
2017
revised:
26
04
2018
accepted:
27
04
2018
pubmed:
26
5
2018
medline:
27
4
2019
entrez:
26
5
2018
Statut:
ppublish
Résumé
Nardilysin (NRDC), a zinc peptidase, exhibits multiple localisation-dependent functions including as an enhancer of ectodomain shedding in the extracellular space and a transcriptional coregulator in the nucleus. In this study, we investigated its functional role in exocrine pancreatic development, homeostasis and the formation of pancreatic ductal adenocarcinoma (PDA). We analysed We found that pancreatic deletion of Nrdc inhibits pancreatitis and suppresses PDA initiation in mice.
Identifiants
pubmed: 29798841
pii: gutjnl-2017-315425
doi: 10.1136/gutjnl-2017-315425
doi:
Substances chimiques
Metalloendopeptidases
EC 3.4.24.-
nardilysin
EC 3.4.24.61
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
882-892Informations de copyright
© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2019. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
Déclaration de conflit d'intérêts
Competing interests: None declared.