ER stress and unfolded protein response in ocular health and disease.
AMD
RGC
RPE
UPR
VEGF
ER stress
achromatopsia
glaucoma
neurodegernation
retinal degeneration
Journal
The FEBS journal
ISSN: 1742-4658
Titre abrégé: FEBS J
Pays: England
ID NLM: 101229646
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
22
12
2017
revised:
07
04
2018
accepted:
24
05
2018
pubmed:
29
5
2018
medline:
19
7
2019
entrez:
27
5
2018
Statut:
ppublish
Résumé
The human eye is the organ that is able to react to light in order to provide sharp three-dimensional and colored images. Unfortunately, the health of the eye can be impacted by various stimuli that can lead to vision loss, such as environmental changes, genetic mutations, or aging. Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) signaling have been detected in many diverse ocular diseases, and chemical and genetic approaches to modulate ER stress and specific UPR regulatory molecules have shown beneficial effects in animal models of eye disease. This review highlights specific eye diseases associated with ER stress and UPR activity, based on a recent symposia exploring this theme.
Identifiants
pubmed: 29802807
doi: 10.1111/febs.14522
pmc: PMC6583901
mid: NIHMS1030034
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
399-412Subventions
Organisme : BLRD VA
ID : I01 BX002284
Pays : United States
Organisme : RRD VA
ID : I01 RX002340
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY027335
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS088485
Pays : United States
Informations de copyright
Published 2018. This article is a U.S. Government work and is in the public domain in the USA.
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