Acetylation
Animals
Cell Differentiation
/ drug effects
Chemokine CCL2
/ drug effects
Chondrogenesis
/ drug effects
Fatty Acids
/ chemistry
Humans
Inflammation
Interleukin-6
/ metabolism
Macrophages
/ drug effects
Mesenchymal Stem Cells
/ drug effects
Mice
Osteoarthritis
/ drug therapy
RAW 264.7 Cells
Tumor Necrosis Factor-alpha
/ drug effects
Waxes
/ pharmacology
adipose-derived stem cells
cetyl myristoleate
cetylated fatty acids
chondrogenesis
inflammation
Journal
Cartilage
ISSN: 1947-6043
Titre abrégé: Cartilage
Pays: United States
ID NLM: 101518378
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
pubmed:
29
5
2018
medline:
10
6
2021
entrez:
30
5
2018
Statut:
ppublish
Résumé
Cetylated fatty acids are a group of naturally occurring fats of plant and/or animal origin. Cetyl myristoleate, in particular, was initially involved in osteoarthritis related research as its therapeutic administration prevented experimentally induced arthritis in Swiss Albino mice. In this context, the aim of our study was to investigate the possible mechanisms of Celadrin cetylated fatty acids action at the cellular level inflammation related pain relief and chondrogenesis. For this, we tested the effects of the cetylated fatty acids mixture from Celadrin on an The cetylated fatty acids mixture from Celadrin significantly decreased the production of IL-6, MCP-1, and TNF, key regulators of the inflammatory process, in stimulated RAW264.7 mouse macrophage cells. The treatment with cetylated fatty acids mixture initiated and propagated the process of chondrogenesis as demonstrated by the increased expression and deposition of chondrogenic markers by the differentiating mesenchymal cells. The cetylated fatty acids mixture from Celadrin reduces inflammation
Identifiants
pubmed: 29808705
doi: 10.1177/1947603518775798
pmc: PMC6921950
doi:
Substances chimiques
Chemokine CCL2
0
Fatty Acids
0
Interleukin-6
0
Tumor Necrosis Factor-alpha
0
Waxes
0
cetyl myristoleate
87P8K33Q5X
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
88-97Références
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