Cellular Senescence-Inducing Small Molecules for Cancer Treatment.
Cancer
DNA damage responses
SASP
senescence
senescence-related signaling pathways
small molecule drugs.
Journal
Current cancer drug targets
ISSN: 1873-5576
Titre abrégé: Curr Cancer Drug Targets
Pays: Netherlands
ID NLM: 101094211
Informations de publication
Date de publication:
2019
2019
Historique:
received:
30
08
2017
revised:
10
02
2018
accepted:
07
03
2018
pubmed:
1
6
2018
medline:
30
5
2020
entrez:
1
6
2018
Statut:
ppublish
Résumé
Recently, the chemotherapeutic drug-induced cellular senescence has been considered a promising anti-cancer approach. The drug-induced senescence, which shows both similar and different hallmarks from replicative and oncogene-induced senescence, was regarded as a key determinant of tumor response to chemotherapy in vitro and in vivo. To date, an amount of effective chemotherapeutic drugs that can evoke senescence in cancer cells have been reported. The targets of these drugs differ substantially, including senescence signaling pathways, DNA replication process, DNA damage pathways, epigenetic modifications, microtubule polymerization, senescence-associated secretory phenotype (SASP), and so on. By summarizing senescence-inducing small molecule drugs together with their specific traits and corresponding mechanisms, this review is devoted to inform scientists to develop novel therapeutic strategies against cancer through inducing senescence.
Identifiants
pubmed: 29848278
pii: CCDT-EPUB-90772
doi: 10.2174/1568009618666180530092825
doi:
Substances chimiques
Antineoplastic Agents
0
Small Molecule Libraries
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
109-119Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.