Towards offline PET monitoring of proton therapy at MedAustron.
Dose verification
GATE simulations
Positron emission tomography
Proton therapy
Journal
Zeitschrift fur medizinische Physik
ISSN: 1876-4436
Titre abrégé: Z Med Phys
Pays: Germany
ID NLM: 100886455
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
04
01
2018
revised:
12
05
2018
accepted:
13
05
2018
pubmed:
3
6
2018
medline:
26
7
2019
entrez:
3
6
2018
Statut:
ppublish
Résumé
The characteristic depth-dose profile of protons traveling through material is the main advantage of proton therapy over conventional radiotherapy with photons or electrons. However, uncertainties regarding the range of the protons in human tissue prevent to exploit the full potential of proton therapy. Therefore, a non-invasive in-vivo dose monitoring is desired. At the ion beam center MedAustron in Wiener Neustadt/Austria, patient treatment with proton beams started in December 2016. A PET/CT is available in close vicinity of the treatment rooms, exclusively dedicated to offline PET monitoring directly after the therapeutic irradiation. Preparations for a patient study include workflow tests under realistic clinical conditions using two different phantoms, irradiated with protons prior to the scan in the PET/CT. GATE simulations of the C-11 production are used as basis for the prediction of the PET measurement. We present results from the workflow tests in comparison with simulation results, and by this, we demonstrate the applicability of the PET monitoring at the MedAustron facility.
Identifiants
pubmed: 29858131
pii: S0939-3889(18)30001-1
doi: 10.1016/j.zemedi.2018.05.003
pii:
doi:
Types de publication
Journal Article
Langues
eng
Pagination
59-65Informations de copyright
Copyright © 2018. Published by Elsevier GmbH.