Activity of xanthine oxidase in plasma correlates with indices of insulin resistance and liver dysfunction in patients with type 2 diabetes mellitus and metabolic syndrome: A pilot exploratory study.
Insulin resistance
Uric acid
Xanthine oxidase
Journal
Journal of diabetes investigation
ISSN: 2040-1124
Titre abrégé: J Diabetes Investig
Pays: Japan
ID NLM: 101520702
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
22
02
2018
revised:
04
05
2018
accepted:
31
05
2018
pubmed:
5
6
2018
medline:
15
2
2019
entrez:
5
6
2018
Statut:
ppublish
Résumé
There is controversy as to whether hyperuricemia is an independent risk factor for cardiometabolic diseases. The serum level of uric acid is affected by a wide variety of factors involved in its production and excretion. In contrast, evidence has accumulated that locally- and systemically-activated xanthine oxidase (XO), a rate-limiting enzyme for production of uric acid, is linked to metabolic derangement in humans and rodents. We therefore explored the clinical implication of plasma XO activity in patients with type 2 diabetes mellitus and metabolic syndrome (MetS). We enrolled 60 patients with type 2 diabetes mellitus and MetS. MetS was defined according to the 2005 International Diabetes Federation guidelines. Plasma XO activity was measured by highly-sensitive fluorometric assay measuring the conversion of pterin to isoxanthopterin, and explored associations between the value of plasma XO activity and metabolic parameters. The value of plasma XO activity was correlated with indices of insulin resistance and the level of circulating liver transaminases. In contrast, the level of serum uric acid was not correlated with indices of insulin resistance. The value of plasma XO activity was not correlated with the serum uric acid level. Plasma XO activity correlates with indices of insulin resistance and liver dysfunction in Japanese patients with type 2 diabetes mellitus and MetS. Through assessing the plasma XO activity, patients showing normal levels of serum uric acid with higher activity of XO can be screened, thereby possibly providing a clue to uncovering metabolic risks in type 2 diabetes mellitus and MetS patients.
Identifiants
pubmed: 29862667
doi: 10.1111/jdi.12870
pmc: PMC6319612
doi:
Substances chimiques
Xanthine Oxidase
EC 1.17.3.2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
94-103Subventions
Organisme : Japan Society for the Promotion of Science
ID : 15K19520
Organisme : Japan Society for the Promotion of Science
ID : 24591338
Organisme : Council for Science, Technology and Innovation
Organisme : Cross-ministerial Strategic Innovation Promotion Program
Organisme : Technologies for Creating Next-generation Agriculture, Forestry and Fisheries
Organisme : Lotte Foundation
Organisme : Japan Foundation for Applied Enzymology
Organisme : New Energy and Industrial Technology Development Organization
Organisme : Project for formation of life science network (Pharmaceutical field)
Organisme : Promotion Project of Medical Clustering of Okinawa prefecture
Organisme : Okinawa Prefecture for Promotion of Advanced Medicine
Informations de copyright
© 2018 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
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