Post-Mortem Magnetic Resonance Imaging Appearances of Feticide in Perinatal Deaths.


Journal

Fetal diagnosis and therapy
ISSN: 1421-9964
Titre abrégé: Fetal Diagn Ther
Pays: Switzerland
ID NLM: 9107463

Informations de publication

Date de publication:
2019
Historique:
received: 16 01 2018
accepted: 30 03 2018
pubmed: 7 6 2018
medline: 24 8 2019
entrez: 7 6 2018
Statut: ppublish

Résumé

The aim of this study was to characterise the imaging features seen in fetuses having undergone feticide by intracardiac potassium chloride injection compared to those of non-terminated fetuses at post-mortem magnetic resonance imaging (PMMRI). A case-control study was performed comparing PMMRI findings between two groups of patients - those having undergone feticide were matched to a control group of miscarried/stillborn fetuses. The groups were matched according to gestational age, weight, and time since death. Two independent readers reviewed the PMMRI for thoracic, abdominal, and musculoskeletal imaging features. The Fishers exact test was conducted for differences between the patient groups. Twenty-six cases of feticide (mean gestation 25 weeks [20-36]) and 75 non-terminated fetuses (mean gestation 26.7 weeks [19-36]) were compared. There was a higher proportion of feticide cases demonstrating pneumothorax (23.1 vs. 1.3%, p = 0.001), haemothorax (42.3 vs. 4%, p = 0.001), pneumopericardium (30.8 vs. 5.3%, p = 0.002), and haemopericardium (34.6 vs. 0%, p = 0.0001). Intracardiac gas and intra-abdominal findings were higher in the feticide group, but the differences were not statistically significant. Characteristic PMMRI features of feticide can help improve reporter confidence in differentiating iatrogenic from physiological/pathological processes.

Identifiants

pubmed: 29874643
pii: 000488940
doi: 10.1159/000488940
doi:

Substances chimiques

Potassium Chloride 660YQ98I10

Types de publication

Journal Article

Langues

eng

Pagination

221-229

Subventions

Organisme : Department of Health
ID : CDF-2017-10-037
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R002118/1
Pays : United Kingdom

Informations de copyright

© 2018 S. Karger AG, Basel.

Auteurs

Susan C Shelmerdine (SC)

Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom, susan.shelmerdine@gosh.nhs.uk.

Melissa Hickson (M)

Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.

Neil J Sebire (NJ)

Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.
UCL Great Ormond Street Institute of Child Health, London, United Kingdom.

Owen J Arthurs (OJ)

Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.
UCL Great Ormond Street Institute of Child Health, London, United Kingdom.

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