Emergent Functional Network Effects in Parkinson Disease.
Parkinson disease
fMRI
functional connectivity
networks
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
01 06 2019
01 06 2019
Historique:
received:
08
05
2018
pubmed:
8
6
2018
medline:
23
9
2020
entrez:
8
6
2018
Statut:
ppublish
Résumé
The hallmark pathology underlying Parkinson disease (PD) is progressive synucleinopathy, beginning in caudal brainstem that later spreads rostrally. However, the primarily subcortical pathology fails to account for the wide spectrum of clinical manifestations in PD. To reconcile these observations, resting-state functional connectivity (FC) can be used to examine dysfunction across distributed brain networks. We measured FC in a large, single-site study of nondemented PD (N = 107; OFF medications) and healthy controls (N = 46) incorporating rigorous quality control measures and comprehensive sampling of cortical, subcortical and cerebellar regions. We employed novel statistical approaches to determine group differences across the entire connectome, at the network-level, and for select brain regions. Group differences respected well-characterized network delineations producing a striking "block-wise" pattern of network-to-network effects. Surprisingly, these results demonstrate that the greatest FC differences involve sensorimotor, thalamic, and cerebellar networks, with notably smaller striatal effects. Split-half replication demonstrates the robustness of these results. Finally, block-wise FC correlations with behavior suggest that FC disruptions may contribute to clinical manifestations in PD. Overall, these results indicate a concerted breakdown of functional network interactions, remote from primary pathophysiology, and suggest that FC deficits in PD are related to emergent network-level phenomena rather than focal pathology.
Identifiants
pubmed: 29878081
pii: 5033557
doi: 10.1093/cercor/bhy121
pmc: PMC6519699
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2509-2523Subventions
Organisme : NINDS NIH HHS
ID : R01 NS058714
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS075321
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS097437
Pays : United States
Organisme : NINDS NIH HHS
ID : P30 NS098577
Pays : United States
Organisme : NINDS NIH HHS
ID : F32 NS092290
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH104592
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© The Author(s) 2018. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
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