Arterial lesions in giant cell arteritis: A longitudinal study.
Aortic aneurysm
Computed tomography angiography
Disease activity
Giant cell arteritis
Large-artery stenosis
Magnetic resonance angiography
Journal
Seminars in arthritis and rheumatism
ISSN: 1532-866X
Titre abrégé: Semin Arthritis Rheum
Pays: United States
ID NLM: 1306053
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
19
02
2018
revised:
25
04
2018
accepted:
07
05
2018
pubmed:
9
6
2018
medline:
24
4
2019
entrez:
9
6
2018
Statut:
ppublish
Résumé
To evaluate large-vessel (LV) abnormalities on serial imaging in patients with giant cell arteritis (GCA) and discern predictors of new lesions. Clinical and imaging data from patients with GCA (including subjects diagnosed by LV imaging) enrolled in a prospective, multicenter, longitudinal study and/or a randomized clinical trial were included. New arterial lesions were defined as a lesion in a previously unaffected artery. The study included 187 patients with GCA, 146 (78%) female, mean (±SD) age at diagnosis 68.5 ± 8.5 years; 39% diagnosed by LV imaging. At least one arterial lesion was present in 123 (66%) on the first study. The most frequently affected arteries were subclavian (42%), axillary (32%), and thoracic aorta (20%). In 106 patients (57%) with serial imaging, new arterial lesions were noted in 41 patients (39%), all of whom had a baseline abnormality, over a mean (±SD) follow-up of 4.39 (2.22) years. New abnormalities were observed in 33% patients by year 2; clinical features of active disease were present at only 50% of these cases. There were no differences in age, sex, temporal artery biopsy positivity, or disease activity in patients with or without new lesions. In this cohort of patients with GCA, LV abnormalities on first imaging were common. Development of new arterial lesions occurred in patients with arterial abnormalities at first imaging, often in the absence of symptoms of active disease. Arterial imaging should be considered in all patients with GCA at diagnosis and serial imaging at least in patients with baseline abnormalities.
Identifiants
pubmed: 29880442
pii: S0049-0172(18)30094-5
doi: 10.1016/j.semarthrit.2018.05.002
pmc: PMC6226363
mid: NIHMS976730
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
707-713Subventions
Organisme : NIAMS NIH HHS
ID : U54 AR057319
Pays : United States
Organisme : NCRR NIH HHS
ID : U54 RR019497
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.
Références
Medicine (Baltimore). 2009 May;88(3):182-92
pubmed: 19440121
Arthritis Rheum. 2003 Dec;48(12):3522-31
pubmed: 14674004
N Engl J Med. 2017 Jul 27;377(4):317-328
pubmed: 28745999
Ann Rheum Dis. 2015 Jan;74(1):129-35
pubmed: 24095936
J Rheumatol. 2015 Dec;42(12):2465-9
pubmed: 26077399
J Rheumatol. 2001 Jun;28(6):1407-12
pubmed: 11409140
AJR Am J Roentgenol. 1976 Dec;127(6):957-63
pubmed: 11699
Medicine (Baltimore). 2011 Jan;90(1):40-51
pubmed: 21200185
Ann Rheum Dis. 2012 Jul;71(7):1170-6
pubmed: 22267328
Arthritis Rheumatol. 2018 Mar;70(3):439-449
pubmed: 29145713
Semin Arthritis Rheum. 1995 Jun;24(6):422-31
pubmed: 7667646
Ann Rheum Dis. 2018 May;77(5):636-643
pubmed: 29358285
Rheumatology (Oxford). 2008 Sep;47(9):1406-8
pubmed: 18625659
Arthritis Rheum. 1999 Feb;42(2):311-7
pubmed: 10025926
Ann Intern Med. 1975 Dec;83(6):806-12
pubmed: 1200525
Arthritis Rheum. 2008 May 15;59(5):670-6
pubmed: 18438900
Ann Rheum Dis. 2010 Jul;69(7):1356-9
pubmed: 20498213
J Rheumatol. 2012 Feb;39(2):303-9
pubmed: 22174204
J Rheumatol. 2011 Jul;38(7):1471-9
pubmed: 21724719
Ann Rheum Dis. 2012 Aug;71(8):1329-34
pubmed: 22328740
Autoimmun Rev. 2018 Apr;17(4):391-398
pubmed: 29427822
Arthritis Rheum. 2006 Feb 15;55(1):131-7
pubmed: 16463425
Ann Rheum Dis. 2014 Jul;73(7):1388-92
pubmed: 24665112
Rheumatology (Oxford). 2015 Mar;54(3):463-70
pubmed: 25193809
Ann Intern Med. 1995 Apr 1;122(7):502-7
pubmed: 7872584
Ann Rheum Dis. 2013 Dec;72(12):1989-94
pubmed: 23253927
Arthritis Care Res (Hoboken). 2014 Jan;66(1):113-9
pubmed: 24106211
Rheumatology (Oxford). 2008 Jan;47(1):96-101
pubmed: 18077499
Arthritis Rheumatol. 2017 Apr;69(4):837-845
pubmed: 28133925
Rheumatology (Oxford). 2012 Apr;51(4):730-4
pubmed: 22179725
Scand J Rheumatol. 2012 May;41(3):231-6
pubmed: 22400812
Ann Rheum Dis. 2014 Oct;73(10):1826-32
pubmed: 23873881
Arthritis Rheum. 2009 Oct 15;61(10):1454-61
pubmed: 19790127
Arthritis Rheum. 2008 Mar 15;59(3):422-30
pubmed: 18311764
Arthritis Rheum. 1990 Aug;33(8):1122-8
pubmed: 2202311