Timing in the treatment of status epilepticus: From basics to the clinic.

Adolescent Adult Animals Anticonvulsants / administration & dosage Child Humans Status Epilepticus / drug therapy Time-to-Treatment Young Adult
Children Epilepsy Status epilepticus Treatment delay

Journal

Seizure
ISSN: 1532-2688
Titre abrégé: Seizure
Pays: England
ID NLM: 9306979

Informations de publication

Date de publication:
May 2019
Historique:
received: 15 04 2018
revised: 18 05 2018
accepted: 29 05 2018
pubmed: 10 6 2018
medline: 18 12 2019
entrez: 10 6 2018
Statut: ppublish

Résumé

Describe basic science, animal models and clinical data related to timing of treatment in status epilepticus (SE). We summarized the results of 15 studies that reported time to treatment in SE, and reviewed basic and clinical literature. SE is a life-threatening and time-sensitive emergency that requires immediate treatment. Current guidelines recommend escalation of anti-seizure medications (ASM) within specified time frames. Prolonged seizures may lead to changes in the composition and location of gamma-aminobutyric acid A receptors (GABA Morbidity and mortality may be avoided with rapid, effective treatment of SE. Treatment application and escalation remains delayed especially in outpatient settings, potentially leading to suboptimal outcomes. Implementation techniques and quality improvement methodologies may provide avenues for improving outcomes in SE.

Identifiants

DOI: 10.1016/j.seizure.2018.05.021 PMID: 29884518
pubmed: 29884518
pii: S1059-1311(18)30235-8
doi: 10.1016/j.seizure.2018.05.021
pii:
doi:

Substances chimiques

Anticonvulsants 0

Types de publication

Journal Article Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

22-30

Informations de copyright

Copyright © 2018 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

Auteurs

Marina Gaínza-Lein (M)

Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile. Electronic address: m.gainzalein@gmail.com.

Iván Sánchez Fernández (IS)

Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Child Neurology, Hospital Sant Joan de Déu, Universidad de Barcelona, Spain. Electronic address: ivan.fernandez@childrens.harvard.edu.

Adriana Ulate-Campos (A)

Department of Neurology, National Children's Hospital "Dr. Carlos Saenz Herrera", San José, Costa Rica. Electronic address: adrianaulate@hotmail.com.

Tobias Loddenkemper (T)

Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: tobias.loddenkemper@childrens.harvard.edu.

Adam P Ostendorf (AP)

Neurology Division, Department of Pediatrics, The Ohio State University and Nationwide Children's Hospital, Columbus, OH, USA. Electronic address: Adam.Ostendorf@nationwidechildrens.org.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Timing in the treatment of status epilepticus:...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Timing in the treatment of status epilepticus:...
questionsmedicales.fr › Eucaryotes › Animaux › Timing in the treatment of status epilepticus:...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Anticonvulsivants › Timing in the treatment of status epilepticus:...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Timing in the treatment of status epilepticus:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Timing in the treatment of status epilepticus:...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Crises épileptiques › État de mal épileptique › Timing in the treatment of status epilepticus:...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Soins aux patients › Délai jusqu'au traitement › Timing in the treatment of status epilepticus:...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Timing in the treatment of status epilepticus:...