The Therapeutic Role of Xenobiotic Nuclear Receptors Against Metabolic Syndrome.
Constitutive Androstane Receptor (CAR)
Farnesoid X Receptor (FXR)
Liver
X Receptor (LXR)
Peroxisome Proliferator-Activated Receptor (PPAR)
Pregnane X Receptor (PXR)
Xenobiotic Nuclear Receptors (XNRs)
diabetes.
Journal
Current drug metabolism
ISSN: 1875-5453
Titre abrégé: Curr Drug Metab
Pays: Netherlands
ID NLM: 100960533
Informations de publication
Date de publication:
2019
2019
Historique:
received:
14
03
2018
revised:
05
04
2018
accepted:
29
05
2018
pubmed:
12
6
2018
medline:
25
7
2019
entrez:
12
6
2018
Statut:
ppublish
Résumé
Diabetes, with an increased prevalence and various progressive complications, has become a significant global health challenge. The concrete mechanisms responsible for the development of diabetes still remain incompletely unknown, although substantial researches have been conducted to search for the effective therapeutic targets. This review aims to reveal the novel roles of Xenobiotic Nuclear Receptors (XNRs), including the Peroxisome Proliferator-Activated Receptor (PPAR), the Farnesoid X Receptor (FXR), the Liver X Receptor (LXR), the Pregnane X Receptor (PXR) and the Constitutive Androstane Receptor (CAR), in the development of diabetes and provide potential strategies for research and treatment of metabolic diseases. We retrieved a large number of original data about these five XNRs and organized to focus on their recently discovered functions in diabetes and its complications. Increasing evidences have suggested that PPAR, FXR, LXR ,PXR and CAR are involved in the development of diabetes and its complications through different mechanisms, including the regulation of glucose and lipid metabolism, insulin and inflammation response and related others. PPAR, FXR, LXR, PXR, and CAR, as the receptors for numerous natural or synthetic compounds, may be the most effective therapeutic targets in the treatment of metabolic diseases.
Sections du résumé
BACKGROUND
BACKGROUND
Diabetes, with an increased prevalence and various progressive complications, has become a significant global health challenge. The concrete mechanisms responsible for the development of diabetes still remain incompletely unknown, although substantial researches have been conducted to search for the effective therapeutic targets. This review aims to reveal the novel roles of Xenobiotic Nuclear Receptors (XNRs), including the Peroxisome Proliferator-Activated Receptor (PPAR), the Farnesoid X Receptor (FXR), the Liver X Receptor (LXR), the Pregnane X Receptor (PXR) and the Constitutive Androstane Receptor (CAR), in the development of diabetes and provide potential strategies for research and treatment of metabolic diseases.
METHODS
METHODS
We retrieved a large number of original data about these five XNRs and organized to focus on their recently discovered functions in diabetes and its complications.
RESULTS
RESULTS
Increasing evidences have suggested that PPAR, FXR, LXR ,PXR and CAR are involved in the development of diabetes and its complications through different mechanisms, including the regulation of glucose and lipid metabolism, insulin and inflammation response and related others.
CONCLUSION
CONCLUSIONS
PPAR, FXR, LXR, PXR, and CAR, as the receptors for numerous natural or synthetic compounds, may be the most effective therapeutic targets in the treatment of metabolic diseases.
Identifiants
pubmed: 29886826
pii: CDM-EPUB-91023
doi: 10.2174/1389200219666180611083155
doi:
Substances chimiques
Constitutive Androstane Receptor
0
Liver X Receptors
0
Peroxisome Proliferator-Activated Receptors
0
Pregnane X Receptor
0
Receptors, Cytoplasmic and Nuclear
0
Xenobiotics
0
farnesoid X-activated receptor
0C5V0MRU6P
Types de publication
Journal Article
Review
Langues
eng
Pagination
15-22Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.