Subtle Modifications to the Indole-2-carboxamide Motif of the Negative Allosteric Modulator N-(( trans)-4-(2-(7-Cyano-3,4-dihydroisoquinolin-2(1 H)-yl)ethyl)cyclohexyl)-1 H-indole-2-carboxamide (SB269652) Yield Dramatic Changes in Pharmacological Activity at the Dopamine D
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
10 01 2019
10 01 2019
Historique:
pubmed:
12
6
2018
medline:
15
10
2019
entrez:
12
6
2018
Statut:
ppublish
Résumé
SB269652 (1) is a negative allosteric modulator of the dopamine D
Identifiants
pubmed: 29890071
doi: 10.1021/acs.jmedchem.8b00192
doi:
Substances chimiques
1H-indole-2-carboxylic acid (4-(2-(cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl)cyclohexyl)amide
0
Amides
0
Indoles
0
Isoquinolines
0
Receptors, Dopamine D2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM