White matter injury in term neonates with congenital heart diseases: Topology & comparison with preterm newborns.
Congenital heart disease (CHD)
Preterm neonates
Probabilistic WMI map
Term CHD neonates
Topology
White matter injury (WMI)
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
15 01 2019
15 01 2019
Historique:
received:
19
10
2017
revised:
28
05
2018
accepted:
04
06
2018
pubmed:
12
6
2018
medline:
6
4
2019
entrez:
12
6
2018
Statut:
ppublish
Résumé
Neonates with congenital heart disease (CHD) are at high risk of punctate white matter injury (WMI) and impaired brain development. We hypothesized that WMI in CHD neonates occurs in a characteristic distribution that shares topology with preterm WMI and that lower birth gestational age (GA) is associated with larger WMI volume. (1) To quantitatively assess the volume and location of WMI in CHD neonates across three centres. (2) To compare the volume and spatial distribution of WMI between term CHD neonates and preterm neonates using lesion mapping. In 216 term born CHD neonates from three prospective cohorts (mean birth GA: 39 weeks), WMI was identified in 86 neonates (UBC: 29; UCSF: 43; UCZ: 14) on pre- and/or post-operative T1 weighted MRI. WMI was manually segmented and volumes were calculated. A standard brain template was generated. Probabilistic WMI maps (total, pre- and post-operative) were developed in this common space. Using these maps, WMI in the term CHD neonates was compared with that in preterm neonates: 58 at early-in-life (mean postmenstrual age at scan 32.2 weeks); 41 at term-equivalent age (mean postmenstrual age at scan 40.1 weeks). The total WMI volumes of CHD neonates across centres did not differ (p = 0.068): UBC (median = 84.6 mm WMI in term neonates with CHD occurs in a characteristic topology. The spatial distribution of WMI in term neonates with CHD reflects the expected maturation of pre-oligodendrocytes such that the central regions are less vulnerable than in the preterm neonates.
Sections du résumé
BACKGROUND
Neonates with congenital heart disease (CHD) are at high risk of punctate white matter injury (WMI) and impaired brain development. We hypothesized that WMI in CHD neonates occurs in a characteristic distribution that shares topology with preterm WMI and that lower birth gestational age (GA) is associated with larger WMI volume.
OBJECTIVE
(1) To quantitatively assess the volume and location of WMI in CHD neonates across three centres. (2) To compare the volume and spatial distribution of WMI between term CHD neonates and preterm neonates using lesion mapping.
METHODS
In 216 term born CHD neonates from three prospective cohorts (mean birth GA: 39 weeks), WMI was identified in 86 neonates (UBC: 29; UCSF: 43; UCZ: 14) on pre- and/or post-operative T1 weighted MRI. WMI was manually segmented and volumes were calculated. A standard brain template was generated. Probabilistic WMI maps (total, pre- and post-operative) were developed in this common space. Using these maps, WMI in the term CHD neonates was compared with that in preterm neonates: 58 at early-in-life (mean postmenstrual age at scan 32.2 weeks); 41 at term-equivalent age (mean postmenstrual age at scan 40.1 weeks).
RESULTS
The total WMI volumes of CHD neonates across centres did not differ (p = 0.068): UBC (median = 84.6 mm
CONCLUSIONS
WMI in term neonates with CHD occurs in a characteristic topology. The spatial distribution of WMI in term neonates with CHD reflects the expected maturation of pre-oligodendrocytes such that the central regions are less vulnerable than in the preterm neonates.
Identifiants
pubmed: 29890324
pii: S1053-8119(18)30511-1
doi: 10.1016/j.neuroimage.2018.06.004
pmc: PMC6289608
mid: NIHMS977202
pii:
doi:
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
742-749Subventions
Organisme : NINDS NIH HHS
ID : R01 NS040117
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR001271
Pays : United States
Organisme : NINDS NIH HHS
ID : P01 NS082330
Pays : United States
Organisme : NINDS NIH HHS
ID : K23 NS099422
Pays : United States
Organisme : NINDS NIH HHS
ID : P50 NS035902
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS063876
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.
Références
Pediatr Neurol. 2014 Sep;51(3):377-83
pubmed: 25160542
Pediatr Res. 2016 Aug;80(2):172-7
pubmed: 27055190
Clin Perinatol. 2014 Mar;41(1):1-24
pubmed: 24524444
Ann Neurol. 2006 Apr;59(4):640-51
pubmed: 16450369
Circulation. 2016 May 17;133(20):1951-62
pubmed: 27185022
Circulation. 2010 Jan 5;121(1):26-33
pubmed: 20026783
Pediatr Res. 2009 Jan;65(1):85-9
pubmed: 18787422
Circ Res. 2017 Mar 17;120(6):960-977
pubmed: 28302742
J Thorac Cardiovasc Surg. 2009 Mar;137(3):529-36; discussion 536-7
pubmed: 19258059
Ment Retard Dev Disabil Res Rev. 2000;6(1):1-5
pubmed: 10899791
Ann N Y Acad Sci. 2010 Jan;1184:68-86
pubmed: 20146691
J Pediatr. 2015 Dec;167(6):1259-63.e1
pubmed: 26233604
J Thorac Cardiovasc Surg. 2004 Dec;128(6):841-9
pubmed: 15573068
J Thorac Cardiovasc Surg. 2010 Mar;139(3):543-56
pubmed: 19909994
J Thorac Cardiovasc Surg. 2016 Oct;152(4):1095-103
pubmed: 27349283
PLoS One. 2012;7(1):e30178
pubmed: 22272298
Sci Rep. 2017 Oct 16;7(1):13250
pubmed: 29038505
Circulation. 2013 Mar 5;127(9):971-9
pubmed: 23371931
Ann Thorac Surg. 2004 May;77(5):1698-706
pubmed: 15111170
Pediatr Res. 2011 Jun;69(6):561-6
pubmed: 21386750
Cereb Cortex. 2002 May;12(5):536-44
pubmed: 11950771
JAMA Pediatr. 2016 Apr;170(4):e154450
pubmed: 26902528
Semin Fetal Neonatal Med. 2013 Oct;18(5):279-85
pubmed: 23706956
Circulation. 2002 Sep 24;106(12 Suppl 1):I109-14
pubmed: 12354718
Med Image Anal. 2008 Feb;12(1):26-41
pubmed: 17659998
N Engl J Med. 2007 Nov 8;357(19):1928-38
pubmed: 17989385
J Am Coll Cardiol. 2018 May 8;71(18):1986-1996
pubmed: 29724352
Stroke. 2007 Feb;38(2 Suppl):736-41
pubmed: 17261728
Neuroradiology. 2013 Sep;55 Suppl 2:23-40
pubmed: 23832006
Front Neuroinform. 2014 Jul 30;8:67
pubmed: 25126069
PLoS One. 2013 Jul 09;8(7):e68098
pubmed: 23874510
Neurology. 2017 Feb 14;88(7):614-622
pubmed: 28100727
J Neurosci. 2006 Mar 15;26(11):3045-55
pubmed: 16540583
Neurology. 2013 Jul 16;81(3):241-8
pubmed: 23771484
Neuroimage Clin. 2018 May 01;19:360-373
pubmed: 30013919
Brain. 2014 Jan;137(Pt 1):268-76
pubmed: 24277720
Circulation. 2015 Apr 14;131(15):1313-23
pubmed: 25762062
Nat Neurosci. 2010 Jun;13(6):690-9
pubmed: 20436478
J Pediatr. 2010 Jun;156(6):882-888.e1
pubmed: 20227731
J Thorac Cardiovasc Surg. 2010 Sep;140(3):550-7
pubmed: 20434174
Pediatr Neurol. 2015 Oct;53(4):330-7
pubmed: 26216502
Ann Neurol. 2014 Apr;75(4):469-86
pubmed: 24615937
J Thorac Cardiovasc Surg. 2012 Mar;143(3):535-42
pubmed: 22340027
Ann Neurol. 2012 Jan;71(1):93-109
pubmed: 22275256
Circulation. 2009 Feb 10;119(5):709-16
pubmed: 19171858
Cereb Cortex. 2013 Dec;23(12):2932-43
pubmed: 22977063
Pediatrics. 2017 Oct;140(4):null
pubmed: 28885171