Genetics of attention deficit hyperactivity disorder.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
29
08
2017
accepted:
19
02
2018
revised:
31
01
2018
pubmed:
13
6
2018
medline:
4
12
2019
entrez:
13
6
2018
Statut:
ppublish
Résumé
Decades of research show that genes play an vital role in the etiology of attention deficit hyperactivity disorder (ADHD) and its comorbidity with other disorders. Family, twin, and adoption studies show that ADHD runs in families. ADHD's high heritability of 74% motivated the search for ADHD susceptibility genes. Genetic linkage studies show that the effects of DNA risk variants on ADHD must, individually, be very small. Genome-wide association studies (GWAS) have implicated several genetic loci at the genome-wide level of statistical significance. These studies also show that about a third of ADHD's heritability is due to a polygenic component comprising many common variants each having small effects. From studies of copy number variants we have also learned that the rare insertions or deletions account for part of ADHD's heritability. These findings have implicated new biological pathways that may eventually have implications for treatment development.
Identifiants
pubmed: 29892054
doi: 10.1038/s41380-018-0070-0
pii: 10.1038/s41380-018-0070-0
pmc: PMC6477889
mid: NIHMS1022091
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
562-575Subventions
Organisme : NIMH NIH HHS
ID : R01 MH101519
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH085518
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH109536
Pays : United States
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