Decorporation potential of lansoprazole against radiothallium (
H/K ATPase inhibitor
Lansoprazole
decorporation
gamma scintigraphy
radiothallium
Journal
Human & experimental toxicology
ISSN: 1477-0903
Titre abrégé: Hum Exp Toxicol
Pays: England
ID NLM: 9004560
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
pubmed:
19
6
2018
medline:
29
3
2019
entrez:
19
6
2018
Statut:
ppublish
Résumé
This study examined the decorporation potential of lansoprazole (LNP) as radioactivity decorporation agent for radiothallium ( Animals were divided into three groups, that is, control, pretreatment-1 (1X LNP), and pretreatment-2 (2X LNP). Mice received LNP intraperitoneally, while in rabbits LNP was given through oral route 0.5 and 1.5 h before radiothallium administration, respectively. Mice and rabbits used in the experiment were administered 1.48 and 11.1 MBq radiothallium ( LNP treatment significantly increased the LNP exhibited dose-dependent decorporation potential to effectively enhance the elimination of
Identifiants
pubmed: 29909643
doi: 10.1177/0960327118781929
doi:
Substances chimiques
Proton Pump Inhibitors
0
Thallium Radioisotopes
0
Lansoprazole
0K5C5T2QPG
Thallium-201
H91Z8HBK1B
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM