Altered Cortical and Hippocampal Excitability in TgF344-AD Rats Modeling Alzheimer's Disease Pathology.
Alzheimer’s disease
TgF344-AD
high-voltage spindles
sensory processing
theta oscillation
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
01 06 2019
01 06 2019
Historique:
received:
12
02
2018
revised:
20
04
2018
pubmed:
20
6
2018
medline:
23
9
2020
entrez:
20
6
2018
Statut:
ppublish
Résumé
Current findings suggest that accumulation of amyloid-β (Aβ) and hyperphosphorylated tau in the brain disrupt synaptic function in hippocampal-cortical neuronal networks leading to impairment in cognitive and affective functions in Alzheimer's disease (AD). Development of new disease-modifying AD drugs are challenging due to the lack of predictive animal models and efficacy assays. In the present study we recorded neural activity in TgF344-AD rats, a transgenic model with a full array of AD pathological features, including age-dependent Aβ accumulation, tauopathy, neuronal loss, and cognitive impairments. Under urethane anesthesia, TgF344-AD rats showed significant age-dependent decline in brainstem-elicited hippocampal theta oscillation and decreased theta-phase gamma-amplitude coupling comparing to their age-matched wild-type counterparts. In freely-behaving condition, the power of hippocampal theta oscillation and gamma power during sharp-wave ripples were significantly lower in TgF344-AD rats. Additionally, these rats showed impaired coherence in both intercortical and hippocampal-cortical network dynamics, and increased incidence of paroxysmal high-voltage spindles, which occur during awake, behaviorally quiescent state. TgF344-AD rats demonstrated impairments in sensory processing, having diminished auditory gating and 40-Hz auditory evoked steady-state response. The observed differences in neurophysiological activities in TgF344-AD rats, which mirror several abnormalities described in AD patients, may be used as promising markers to monitor disease-modifying therapies.
Identifiants
pubmed: 29920597
pii: 5039145
doi: 10.1093/cercor/bhy140
pmc: PMC7302691
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2716-2727Informations de copyright
© The Author(s) 2018. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
Références
Hippocampus. 2015 Oct;25(10):1073-188
pubmed: 26135716
Int J Psychophysiol. 2016 May;103:88-102
pubmed: 25660305
Neuron. 2007 Sep 6;55(5):697-711
pubmed: 17785178
Eur J Neurosci. 2013 Jun;37(12):1896-902
pubmed: 23773058
Nat Commun. 2016 Nov 04;7:13249
pubmed: 27811848
Neurobiol Aging. 1981 Summer;2(2):99-104
pubmed: 7197758
Cereb Cortex. 2013 May;23(5):1148-58
pubmed: 22581851
Sci Rep. 2017 Apr 12;7:46427
pubmed: 28401931
Neuroscience. 2015 Feb 12;286:251-63
pubmed: 25484360
Hippocampus. 2000;10(4):380-8
pubmed: 10985277
Brain Res Bull. 1994;33(2):183-8
pubmed: 8275337
Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17356-61
pubmed: 20855620
J Alzheimers Dis. 2015;44(2):397-408
pubmed: 25261446
Nat Neurosci. 2015 Nov;18(11):1623-30
pubmed: 26457554
Nature. 2016 Dec 7;540(7632):230-235
pubmed: 27929004
Behav Genet. 2003 Nov;33(6):635-55
pubmed: 14574120
J Neurosci. 2013 Apr 10;33(15):6245-56
pubmed: 23575824
Eur Neuropsychopharmacol. 2013 Aug;23(8):988-97
pubmed: 22974558
Brain Res. 2004 Aug 13;1017(1-2):130-6
pubmed: 15261108
Science. 2002 Oct 25;298(5594):789-91
pubmed: 12399581
Neurobiol Aging. 2010 Mar;31(3):416-24
pubmed: 18562045
Hippocampus. 2005;15(7):923-35
pubmed: 16149083
Philos Trans R Soc Lond B Biol Sci. 2009 May 12;364(1521):1193-201
pubmed: 19528000
Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3561-6
pubmed: 19204281
Neuroscience. 2016 Jun 2;324:29-39
pubmed: 26964684
Nat Rev Neurol. 2010 Feb;6(2):67-77
pubmed: 20139996
Trends Pharmacol Sci. 2006 Jul;27(7):391-8
pubmed: 16766049
Hippocampus. 2012 Apr;22(4):748-61
pubmed: 21538660
Science. 2004 Jun 25;304(5679):1926-9
pubmed: 15218136
Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11037-41
pubmed: 1763020
J Neurophysiol. 2007 Jan;97(1):238-47
pubmed: 17035363
Nat Rev Neurol. 2010 Jan;6(1):15-28
pubmed: 20057496
Cell Rep. 2015 May 12;11(6):859-865
pubmed: 25937280
Neuron. 2002 Jan 31;33(3):325-40
pubmed: 11832222
Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3228-33
pubmed: 20133762
Brain Imaging Behav. 2012 Dec;6(4):610-20
pubmed: 22648764
Trends Cogn Sci. 2010 Jun;14(6):277-90
pubmed: 20493761
J Neurosci. 2012 Jan 11;32(2):423-35
pubmed: 22238079
Epilepsy Behav. 2013 Mar;26(3):343-51
pubmed: 23321057
J Neurosci. 2009 Feb 11;29(6):1860-73
pubmed: 19211893
Curr Opin Neurobiol. 2011 Jun;21(3):452-9
pubmed: 21371881
Brain. 2015 Jun;138(Pt 6):1722-37
pubmed: 25732182
J Comp Neurol. 2013 Dec 15;521(18):4124-44
pubmed: 23852922
J Neurosci. 2014 Feb 19;34(8):2832-44
pubmed: 24553925
Nat Rev Drug Discov. 2008 Jan;7(1):68-83
pubmed: 18064038
J Neurosci. 2010 Aug 18;30(33):10991-1003
pubmed: 20720106
Sci Rep. 2016 Mar 07;6:22728
pubmed: 26947247
J Neurosci. 1996 Jul 1;16(13):4240-9
pubmed: 8753885
Nat Rev Neurosci. 2016 Dec;17(12):777-792
pubmed: 27829687
J Neurophysiol. 2014 Oct 1;112(7):1763-74
pubmed: 25008411
Acta Neurobiol Exp (Wars). 2013;73(4):564-70
pubmed: 24457646
J Neurochem. 2018 Mar;144(5):669-679
pubmed: 28777881
Brain. 2008 Jul;131(Pt 7):1806-17
pubmed: 18503077
Neurobiol Aging. 2017 Jan;49:40-51
pubmed: 27743524
Neuroscience. 1992;47(4):823-31
pubmed: 1579212
Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3535-40
pubmed: 25733878
Ann Neurol. 2016 Dec;80(6):858-870
pubmed: 27696483
Neuroscience. 2003;116(2):511-7
pubmed: 12559106
Neurobiol Aging. 2011 Jan;32(1):24-30
pubmed: 19237225
Nat Neurosci. 2009 Oct;12(10):1222-3
pubmed: 19749750
J Neurosci. 2012 Mar 28;32(13):4334-40
pubmed: 22457485
Hippocampus. 2010 Jan;20(1):1-10
pubmed: 19816984
Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20942-7
pubmed: 19934062
Nat Neurosci. 2016 Aug;19(8):1085-92
pubmed: 27322420
Hum Brain Mapp. 1999;8(4):194-208
pubmed: 10619414
J Physiol. 2016 Aug 15;594(16):4615-30
pubmed: 25480798
J Neurosci. 1988 Nov;8(11):4007-26
pubmed: 3183710
Lancet Neurol. 2017 Apr;16(4):311-322
pubmed: 28327340
J Neurosci. 2009 Mar 18;29(11):3453-62
pubmed: 19295151
Nature. 2009 Nov 19;462(7271):353-7
pubmed: 19924214
Neurobiol Aging. 2016 Jan;37:66-73
pubmed: 26610388
Neurobiol Aging. 2016 Sep;45:161-168
pubmed: 27459936
Neurobiol Aging. 2012 Jul;33(7):1481.e13-23
pubmed: 22227005
J Neurosci Methods. 2004 Mar 15;134(1):9-21
pubmed: 15102499