Dual functional bioactive-peptide, AIMP1-derived peptide (AdP), for anti-aging.
Cell Line
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Collagen Type I
/ biosynthesis
Cosmeceuticals
/ pharmacology
Cytokines
Fibroblasts
/ physiology
Humans
Melanins
/ biosynthesis
Melanocytes
/ metabolism
Monophenol Monooxygenase
/ metabolism
Neoplasm Proteins
Peptides
/ pharmacology
Protein Biosynthesis
/ drug effects
RNA-Binding Proteins
Skin Aging
/ drug effects
Skin Lightening Preparations
/ pharmacology
Skin Pigmentation
/ drug effects
Tumor Necrosis Factor-alpha
/ metabolism
AIMP1-derived peptide
anti-wrinkle
cosmeceuticals
sh-oligopeptide-5 SP
whitening
Journal
Journal of cosmetic dermatology
ISSN: 1473-2165
Titre abrégé: J Cosmet Dermatol
Pays: England
ID NLM: 101130964
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
accepted:
02
04
2018
pubmed:
20
6
2018
medline:
14
6
2019
entrez:
20
6
2018
Statut:
ppublish
Résumé
Human skin aging is caused by several factors, such as UV irradiation, stress, hormone, and pollution. Wrinkle formation and skin pigmentation are representative features of skin aging. Although EGF and arbutin are used as anti-wrinkle and skin whitening agents, respectively, they have adverse effects on skin. When more cosmeceutical ingredients are added to cosmetic product, adverse effects are also accumulated. For these reasons, multifunctional and safe cosmetic ingredients are in demand. The aim of the present study is to investigate the novel anti-aging agents, AIMP1-derived peptide (AdP, INCI name: sh-oligopeptide-5/sh-oligopeptide SP) for cosmetic products. To assess the anti-wrinkle effect of AdP, collagen type I synthesis and fibroblast proliferation were determined on human fibroblasts. The anti-wrinkle effect of AdP was examined by ELISA and cell titer glo assay. To assess the whitening, melanin content and tyrosinase activity were determined on melanocytes. The whitening effect of AdP was examined by melanin measurement and enzyme activity assay. The safety of AdP was determined by cytotoxicity and immunogenicity, CCK-8 and TNF-α ELISA assay, respectively. AdP treatment induced the collagen type I synthesis and fibroblast proliferation. Also, AdP treatment inhibited melanin synthesis by regulating tyrosinase activity. The anti-aging effect of AdP is more potent than EGF and albutin. AdP did not show adverse effects. These results show that AdP can be dual functional and safe cosmeceutical agent to prevent skin aging.
Sections du résumé
BACKGROUND
BACKGROUND
Human skin aging is caused by several factors, such as UV irradiation, stress, hormone, and pollution. Wrinkle formation and skin pigmentation are representative features of skin aging. Although EGF and arbutin are used as anti-wrinkle and skin whitening agents, respectively, they have adverse effects on skin. When more cosmeceutical ingredients are added to cosmetic product, adverse effects are also accumulated. For these reasons, multifunctional and safe cosmetic ingredients are in demand. The aim of the present study is to investigate the novel anti-aging agents, AIMP1-derived peptide (AdP, INCI name: sh-oligopeptide-5/sh-oligopeptide SP) for cosmetic products.
METHODS
METHODS
To assess the anti-wrinkle effect of AdP, collagen type I synthesis and fibroblast proliferation were determined on human fibroblasts. The anti-wrinkle effect of AdP was examined by ELISA and cell titer glo assay. To assess the whitening, melanin content and tyrosinase activity were determined on melanocytes. The whitening effect of AdP was examined by melanin measurement and enzyme activity assay. The safety of AdP was determined by cytotoxicity and immunogenicity, CCK-8 and TNF-α ELISA assay, respectively.
RESULTS
RESULTS
AdP treatment induced the collagen type I synthesis and fibroblast proliferation. Also, AdP treatment inhibited melanin synthesis by regulating tyrosinase activity. The anti-aging effect of AdP is more potent than EGF and albutin. AdP did not show adverse effects.
CONCLUSION
CONCLUSIONS
These results show that AdP can be dual functional and safe cosmeceutical agent to prevent skin aging.
Substances chimiques
Collagen Type I
0
Cosmeceuticals
0
Cytokines
0
Melanins
0
Neoplasm Proteins
0
Peptides
0
RNA-Binding Proteins
0
Skin Lightening Preparations
0
Tumor Necrosis Factor-alpha
0
small inducible cytokine subfamily E, member 1
0
Monophenol Monooxygenase
EC 1.14.18.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
251-257Informations de copyright
© 2018 Wiley Periodicals, Inc.