Involvement of mitophagy in cisplatin-induced cell death regulation.
autophagy
cancer therapy
cell death
mitophagy
reactive oxygen species
Journal
Biological chemistry
ISSN: 1437-4315
Titre abrégé: Biol Chem
Pays: Germany
ID NLM: 9700112
Informations de publication
Date de publication:
28 01 2019
28 01 2019
Historique:
received:
06
04
2018
accepted:
14
06
2018
pubmed:
21
6
2018
medline:
1
10
2019
entrez:
21
6
2018
Statut:
ppublish
Résumé
Mitophagy, the selective degradation of mitochondria via the autophagic pathway, is a vital mechanism of mitochondrial quality control in cells. The removal of malfunctioning or damaged mitochondria is essential for normal cellular physiology and tissue development. Stimulation of mitochondrial permeabilization and release of proapoptotic factors from the intermembrane space is an essential step in triggering the mitochondrial pathway of cell death. In this study, we analyzed the extent to which mitophagy interferes with cell death, attenuating the efficiency of cancer therapy. We show that stimulation of mitophagy suppressed cisplatin-induced apoptosis, while mitophagy inhibition stimulates apoptosis and autophagy. Suppression of mitophagy involved production of reactive oxygen species, and the fate of cell was dependent on the interplay between endoplasmic reticulum stress and autophagy.
Identifiants
pubmed: 29924729
doi: 10.1515/hsz-2018-0210
pii: hsz-2018-0210
doi:
Substances chimiques
Antineoplastic Agents
0
Reactive Oxygen Species
0
Cisplatin
Q20Q21Q62J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
161-170Références
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