Effects of PACAP on Dry Eye Symptoms, and Possible Use for Therapeutic Application.
Aging
Dry eye
Neuroprotective function
PACAP
Journal
Journal of molecular neuroscience : MN
ISSN: 1559-1166
Titre abrégé: J Mol Neurosci
Pays: United States
ID NLM: 9002991
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
30
03
2018
accepted:
11
05
2018
pubmed:
23
6
2018
medline:
18
12
2019
entrez:
23
6
2018
Statut:
ppublish
Résumé
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide/glucagon/secretin family of peptides. PACAP and its three receptor subtypes are expressed in neural tissues and in the eye, including the retina, cornea, and lacrimal gland. PACAP is known to exert pleiotropic effects on the central nervous system and in eye tissues where it plays important roles in protecting against dry eye. This review provides an overview of current knowledge regarding dry eye symptoms in aged animals and humans and the protective effects, mechanisms of action. In addition, we also refer to the development of a new preventive/therapeutic method by PACAP of dry eye patients.
Identifiants
pubmed: 29931503
doi: 10.1007/s12031-018-1087-1
pii: 10.1007/s12031-018-1087-1
doi:
Substances chimiques
Neuroprotective Agents
0
Pituitary Adenylate Cyclase-Activating Polypeptide
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
420-426Subventions
Organisme : Japan Society for the Promotion of Science
ID : 2459280, 2459268, 23249079, 15K15670, 16H02684 and 15H01288
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