Impact of dexmedetomidine on the tissue distribution, anesthetic action, and hemodynamic effects of mepivacaine.
Analgesics, Non-Narcotic
/ pharmacokinetics
Anesthetics, Local
/ pharmacokinetics
Animals
Autoradiography
Dexmedetomidine
/ pharmacokinetics
Drug Combinations
Hemodynamics
/ drug effects
Male
Mepivacaine
/ pharmacokinetics
Rats
Rats, Wistar
Regional Blood Flow
/ drug effects
Scintillation Counting
Tissue Distribution
/ drug effects
Dexmedetomidine
Ischemic heart disease and hypertension
Mepivacaine
Pharmacokinetics
Vasoconstriction
Journal
Odontology
ISSN: 1618-1255
Titre abrégé: Odontology
Pays: Japan
ID NLM: 101134822
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
12
02
2018
accepted:
12
05
2018
pubmed:
28
6
2018
medline:
30
6
2019
entrez:
28
6
2018
Statut:
ppublish
Résumé
The present study investigated the regional blood flow, tissue distribution, local anesthetic action, and hemodynamic effects of mepivacaine containing dexmedetomidine hydrochloride (DEX) in rats. Blood flow was measured after injection of 0.5% mepivacaine (M group), 12.5 µg/ml DEX (D group), or 0.5% mepivacaine containing 12.5 µg/ml DEX (DM group) into the upper lip. Mepivacaine distribution was autoradiographically observed in maxillary bone resected after injection of 0.5%
Identifiants
pubmed: 29948489
doi: 10.1007/s10266-018-0368-z
pii: 10.1007/s10266-018-0368-z
doi:
Substances chimiques
Analgesics, Non-Narcotic
0
Anesthetics, Local
0
Drug Combinations
0
Dexmedetomidine
67VB76HONO
Mepivacaine
B6E06QE59J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
29-36Références
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