SNAPshots of the MCHR1: a Comparison Between the PET-Tracers [

Animals Blood Proteins / metabolism CHO Cells Carbon Radioisotopes / chemistry Chromatography, Affinity Cricetinae Cricetulus Fluorine Radioisotopes / chemistry Humans Kinetics Metabolome Mice Piperidines / chemistry Positron-Emission Tomography Protein Binding Pyrimidines / chemistry Rats Receptors, Somatostatin / metabolism Tissue Distribution
Ex vivo In vitro In vivo MCHR1 PET Small animal imaging [11C]SNAP-7941 [18F]FE@SNAP

Journal

Molecular imaging and biology
ISSN: 1860-2002
Titre abrégé: Mol Imaging Biol
Pays: United States
ID NLM: 101125610

Informations de publication

Date de publication:
04 2019
Historique:
pubmed: 28 6 2018
medline: 2 8 2019
entrez: 28 6 2018
Statut: ppublish

Résumé

The melanin-concentrating hormone receptor 1 (MCHR1) has become an important pharmacological target, since it may be involved in various diseases, such as diabetes, insulin resistance, and obesity. Hence, a suitable positron emission tomography radiotracer for the in vivo assessment of the MCHR1 pharmacology is imperative. The current paper contrasts the extensive in vitro, in vivo, and ex vivo assessments of the radiotracers [ Kinetic real-time cell-binding studies with [ [ Both radiotracers demonstrate appropriate imaging properties for the MCHR1. However, the pronounced metabolic stability as well as superior selectivity and affinity of [

Identifiants

DOI: 10.1007/s11307-018-1212-0 PMID: 29948643 PMC: PMC6449294
pubmed: 29948643
doi: 10.1007/s11307-018-1212-0
pii: 10.1007/s11307-018-1212-0
pmc: PMC6449294
doi:

Substances chimiques

Blood Proteins 0
Carbon Radioisotopes 0
Carbon-11 0
Fluorine Radioisotopes 0
MCHR1 protein, human 0
Piperidines 0
Pyrimidines 0
Receptors, Somatostatin 0
SNAP7941 0
Fluorine-18 GZ5I74KB8G

Types de publication

Comparative Study Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Pagination

257-268

Références

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Auteurs

Cécile Philippe (C)

Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Vienna, Austria.

Markus Zeilinger (M)

Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Faculty of Engineering, University of Applied Sciences Wiener Neustadt, Neustadt, Austria.

Monika Dumanic (M)

Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Florian Pichler (F)

Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Faculty of Engineering, University of Applied Sciences Wiener Neustadt, Neustadt, Austria.

Lukas Fetty (L)

Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Department of Radiotherapy, Division of Medical Physics, Medical University of Vienna, Vienna, Austria.

Chrysoula Vraka (C)

Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Theresa Balber (T)

Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Wolfgang Wadsak (W)

Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Department of Inorganic Chemistry, University of Vienna, Vienna, Austria.
CBmed, Graz, Austria.

Katharina Pallitsch (K)

Department of Organic Chemistry, University of Vienna, Vienna, Austria.

Helmut Spreitzer (H)

Department of Pharmaceutical Chemistry, University of Vienna, Vienna, Austria.

Rupert Lanzenberger (R)

Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

Marcus Hacker (M)

Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Markus Mitterhauser (M)

Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. markus.mitterhauser@meduniwien.ac.at.
Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Vienna, Austria. markus.mitterhauser@meduniwien.ac.at.
Ludwig Boltzmann Institute Applied Diagnostics, Vienna, Austria. markus.mitterhauser@meduniwien.ac.at.
ORCID: 0000-0003-3173-5272

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › SNAPshots of the MCHR1: a Comparison Between...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › SNAPshots of the MCHR1: a Comparison Between...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules CHO › SNAPshots of the MCHR1: a Comparison Between...
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Radio-isotopes du carbone › SNAPshots of the MCHR1: a Comparison Between...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Chromatographie d'affinité › SNAPshots of the MCHR1: a Comparison Between...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Cricetinae › SNAPshots of the MCHR1: a Comparison Between...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Cricetinae › Cricetulus › SNAPshots of the MCHR1: a Comparison Between...
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Radio-isotopes du fluor › SNAPshots of the MCHR1: a Comparison Between...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › SNAPshots of the MCHR1: a Comparison Between...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › SNAPshots of the MCHR1: a Comparison Between...
questionsmedicales.fr › Métabolisme › Métabolome › SNAPshots of the MCHR1: a Comparison Between...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › SNAPshots of the MCHR1: a Comparison Between...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › SNAPshots of the MCHR1: a Comparison Between...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › SNAPshots of the MCHR1: a Comparison Between...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › SNAPshots of the MCHR1: a Comparison Between...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › SNAPshots of the MCHR1: a Comparison Between...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › SNAPshots of the MCHR1: a Comparison Between...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormones hypothalamiques hypophysotropes régulatrices › Récepteur somatostatine › SNAPshots of the MCHR1: a Comparison Between...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Distribution tissulaire › SNAPshots of the MCHR1: a Comparison Between...