Mechanism of luminal ATP activated chloride secretion in a polarized epithelium.
ATP
Calcium signaling
Chloride channels
Chloride secretion
Oviduct epithelium
Potassium channels
Purinoceptors
Journal
The journal of physiological sciences : JPS
ISSN: 1880-6562
Titre abrégé: J Physiol Sci
Pays: Japan
ID NLM: 101262417
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
26
04
2018
accepted:
06
06
2018
pubmed:
28
6
2018
medline:
30
5
2019
entrez:
28
6
2018
Statut:
ppublish
Résumé
There are both secretory and absorptive pathways working in tandem to support ionic movement driving fluid secretion across epithelia. The mechanisms exerting control of fluid secretion in the oviduct is yet to be fully determined. This study explored the role of apical or luminal extracellular ATP (ATPe)-stimulated ion transport in an oviduct epithelium model, using the Ussing chamber short-circuit current (Isc) technique. Basal Isc in oviduct epithelium in response to apical ATPe comprises both chloride secretion and sodium absorption and has distinct temporal phases. A rapid transient peak followed by a sustained small increase above baseline. Both phases of the apical ATPe Isc response are sensitive to anion (HCO
Identifiants
pubmed: 29949063
doi: 10.1007/s12576-018-0623-7
pii: 10.1007/s12576-018-0623-7
pmc: PMC10717936
doi:
Substances chimiques
Chloride Channels
0
Chlorides
0
Colforsin
1F7A44V6OU
Adenosine Triphosphate
8L70Q75FXE
Adenosine
K72T3FS567
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
85-95Références
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