Role of immune cells in hypertension.
Journal
British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
16
04
2018
revised:
22
05
2018
accepted:
18
06
2018
pubmed:
29
6
2018
medline:
1
8
2020
entrez:
29
6
2018
Statut:
ppublish
Résumé
Inflammatory processes have been shown to play an important role in the mechanisms involved in the pathogenesis of hypertension. Innate and adaptive immune responses participate in BP elevation and end-organ damage. Here, we discuss recent studies focusing on novel inflammatory and immune mechanisms that play roles in BP elevation. Different subpopulations of cells involved in innate and adaptive immune responses, such as dendritic cells, monocytes/macrophages and NK cells, on the one hand, and B and T lymphocytes, on the other, contribute to the vascular and kidney injury in hypertension. Unconventional innate-like T cells such as γδ T cells also participate in hypertensive mechanisms by priming both innate and adaptive immune cells, contributing to trigger vascular inflammation and BP elevation. These cells exert their effects in part via production of various cytokines including pro-inflammatory IFN-γ and IL-17 and anti-inflammatory IL-10. The present review summarizes some of these immune mechanisms that participate in the pathophysiology of hypertension. LINKED ARTICLES: This article is part of a themed section on Immune Targets in Hypertension. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.12/issuetoc.
Identifiants
pubmed: 29952002
doi: 10.1111/bph.14427
pmc: PMC6534777
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1818-1828Subventions
Organisme : CIHR First Pilot Foundation Grant
ID : 143348
Pays : International
Organisme : CIHR
ID : 123465
Pays : Canada
Organisme : CIHR
ID : 102606
Pays : Canada
Informations de copyright
© 2018 The British Pharmacological Society.
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