The use of a gene expression signature and connectivity map to repurpose drugs for bipolar disorder.

Animals Bipolar Disorder / drug therapy Drug Repositioning Lamotrigine Pharmaceutical Preparations Quetiapine Fumarate Rats Transcriptome
Bipolar disorder CMap drug discovery drug repurposing gene expression signature

Journal

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
ISSN: 1814-1412
Titre abrégé: World J Biol Psychiatry
Pays: England
ID NLM: 101120023

Informations de publication

Date de publication:
12 2020
Historique:
pubmed: 30 6 2018
medline: 28 4 2021
entrez: 30 6 2018
Statut: ppublish

Résumé

To create a gene expression signature (GES) to represent the biological effects of a combination of known drugs for bipolar disorder (BD) on cultured human neuronal cells (NT2-N) and rat brains, which also has evidence of differential expression in individuals with BD. To use the GES to identify new drugs for BD using Connectivity Map (CMap).

Identifiants

DOI: 10.1080/15622975.2018.1492734 PMID: 29956574
pubmed: 29956574
doi: 10.1080/15622975.2018.1492734
doi:

Substances chimiques

Pharmaceutical Preparations 0
Quetiapine Fumarate 2S3PL1B6UJ
Lamotrigine U3H27498KS

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

775-783

Auteurs

Srisaiyini Kidnapillai (S)

Centre for Molecular and Medical Research, School of Medicine, Deakin University, Geelong, Australia.
ORCID: 0000-0001-5313-9813

Chiara C Bortolasci (CC)

Centre for Molecular and Medical Research, School of Medicine, Deakin University, Geelong, Australia.
ORCID: 0000-0002-0794-6363

Madhara Udawela (M)

The Florey Institute of Neuroscience and Mental Health, Parkville, Australia.

Bruna Panizzutti (B)

Laboratory of Molecular Psychiatry, Hospital de Clínicas de Porto Alegre (HCPA) and Programa de Pós-graduação em Psiquiatria e Ciências do Comportamento, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.

Briana Spolding (B)

Centre for Molecular and Medical Research, School of Medicine, Deakin University, Geelong, Australia.

Timothy Connor (T)

Centre for Molecular and Medical Research, School of Medicine, Deakin University, Geelong, Australia.

Andrew Sanigorski (A)

Centre for Molecular and Medical Research, School of Medicine, Deakin University, Geelong, Australia.

Olivia M Dean (OM)

The Florey Institute of Neuroscience and Mental Health, Parkville, Australia.
IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Australia.
Department of Psychiatry, the University of Melbourne, Parkville, Australia.
ORCID: 0000-0002-2776-3935

Tamsyn Crowley (T)

Centre for Molecular and Medical Research, School of Medicine, Deakin University, Geelong, Australia.
Bioinformatics Core Research Facility (BCRF), Deakin University, Geelong, Australia.

Stéphane Jamain (S)

INSERM U955, Psychiatrie Translationnelle, Université Paris Est, Créteil, France.
ORCID: 0000-0002-4321-4100

Laura Gray (L)

Centre for Molecular and Medical Research, School of Medicine, Deakin University, Geelong, Australia.
The Florey Institute of Neuroscience and Mental Health, Parkville, Australia.
ORCID: 0000-0002-7903-5796

Elizabeth Scarr (E)

The Florey Institute of Neuroscience and Mental Health, Parkville, Australia.
Faculty of Veterinary and Agricultural Sciences, Melbourne Veterinary School, The University of Melbourne, Victoria, Australia.

Marion Leboyer (M)

INSERM U955, Psychiatrie Translationnelle, Université Paris Est, Créteil, France.

Brian Dean (B)

The Florey Institute of Neuroscience and Mental Health, Parkville, Australia.
Faculty of Health Arts and Design, Centre for Mental Health, Swinburne University, Victoria, Australia.

Michael Berk (M)

The Florey Institute of Neuroscience and Mental Health, Parkville, Australia.
IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Australia.
Department of Psychiatry, the University of Melbourne, Parkville, Australia.
Orygen, the National, Centre of Excellence in Youth Mental Health, Parkville, Australia.
ORCID: 0000-0002-5554-6946

Ken Walder (K)

Centre for Molecular and Medical Research, School of Medicine, Deakin University, Geelong, Australia.
ORCID: 0000-0002-6758-4763

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The use of a gene expression signature and...
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Troubles bipolaires et apparentés › Trouble bipolaire › The use of a gene expression signature and...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Repositionnement des médicaments › The use of a gene expression signature and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Triazines › Lamotrigine › The use of a gene expression signature and...
questionsmedicales.fr › Préparations pharmaceutiques › The use of a gene expression signature and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Dibenzothiazépines › Fumarate de quétiapine › The use of a gene expression signature and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › The use of a gene expression signature and...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › The use of a gene expression signature and...