Inputs to medullary respiratory neurons from a pontine subregion that controls breathing frequency.
Breathing frequency control
Inspiratory on-switch
Pons
Pre-I neurons
Synaptic input
preBötzinger/Bötzinger complex
Journal
Respiratory physiology & neurobiology
ISSN: 1878-1519
Titre abrégé: Respir Physiol Neurobiol
Pays: Netherlands
ID NLM: 101140022
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
15
02
2018
revised:
10
05
2018
accepted:
04
06
2018
pubmed:
3
7
2018
medline:
3
4
2020
entrez:
3
7
2018
Statut:
ppublish
Résumé
Neurons in a subregion of the medial parabrachial (PB) complex control expiratory duration (TE) and the inspiratory on-switch. To better understanding the underlying mechanisms, this study aimed to determine the types of medullary neurons in the rhythmogenic preBötzinger/Bötzinger Complex (preBötC/BötC) and adjacent areas that receive synaptic inputs from the PB subregion and whether these inputs are excitatory or inhibitory in nature. Highly localized electrical stimuli in the PB subregion combined with multi-electrode recordings from respiratory neurons and phrenic nerve activities were used to generate stimulus-to-spike event histograms to detect correlations in decerebrate, vagotomized dogs during isocapnic hyperoxia. Short-time scale correlations were found in 237/442 or ∼54% of the ventral respiratory column (VRC) neurons. Inhibition of E-neurons was ∼2.5X greater than for I-neurons, while Pre-I and I-neurons were excited. These findings indicate that the control of TE and the inspiratory on-switch by the PB subregion are mediated by a marked inhibition of BötC E-neurons combined with an excitation of I-neurons, especially pre-I neurons.
Identifiants
pubmed: 29964165
pii: S1569-9048(18)30056-9
doi: 10.1016/j.resp.2018.06.011
pmc: PMC6310670
mid: NIHMS982877
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
127-140Subventions
Organisme : BLRD VA
ID : I01 BX000721
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM112960
Pays : United States
Informations de copyright
Published by Elsevier B.V.
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