Rapid Optimization of Reaction Conditions Based on Comprehensive Reaction Analysis Using a Continuous Flow Microwave Reactor.

Acylation design of experiments flow synthesis microwave chemistry optimization

Journal

Chemical record (New York, N.Y.)
ISSN: 1528-0691
Titre abrégé: Chem Rec
Pays: United States
ID NLM: 101085550

Informations de publication

Date de publication:
Jan 2019
Historique:
received: 20 04 2018
accepted: 19 06 2018
pubmed: 4 7 2018
medline: 4 7 2018
entrez: 4 7 2018
Statut: ppublish

Résumé

Generally, the flow method has the advantage of a precise control over the reaction parameters and a facile modification of the reaction conditions, while a continuous flow microwave reactor allows for the quick optimization of reaction conditions owing to the rapid uniform heating. In this study, we developed a "9+4+1 method" to optimize reaction conditions based on comprehensive reaction analysis using a flow microwave reactor. The proposed method is expected to contribute to the synthesis of various fine and bulk chemicals by reducing cost and wastage, and by conserving time.

Identifiants

DOI: 10.1002/tcr.201800048 PMID: 29969189
pubmed: 29969189
doi: 10.1002/tcr.201800048
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

77-84

Subventions

Organisme : Suzuki Foundation's "Exchange program between Shizuoka University and Budapest University of Technology and Economics."

Informations de copyright

© 2019 The Chemical Society of Japan & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Auteurs

Péter Vámosi (P)

Applied Chemistry and Biochemical Engineering Course Department of Engineering, Graduate School of Integrated Science and Technology, Shizuoka University, 3-5-1 Johoku, Hamamatsu, Shizuoka, 432-8561, Japan.
Current address: Department of Organic Chemistry and Organic Chemical Technology, Budapest University of Technology and Economics, 1111, Budapest, Műegyetem rkp. 3, Hungary.

Keiya Matsuo (K)

Applied Chemistry and Biochemical Engineering Course Department of Engineering, Graduate School of Integrated Science and Technology, Shizuoka University, 3-5-1 Johoku, Hamamatsu, Shizuoka, 432-8561, Japan.

Tsuguya Masuda (T)

Applied Chemistry and Biochemical Engineering Course Department of Engineering, Graduate School of Integrated Science and Technology, Shizuoka University, 3-5-1 Johoku, Hamamatsu, Shizuoka, 432-8561, Japan.

Kohei Sato (K)

Applied Chemistry and Biochemical Engineering Course Department of Engineering, Graduate School of Integrated Science and Technology, Shizuoka University, 3-5-1 Johoku, Hamamatsu, Shizuoka, 432-8561, Japan.

Tetsuo Narumi (T)

Applied Chemistry and Biochemical Engineering Course Department of Engineering, Graduate School of Integrated Science and Technology, Shizuoka University, 3-5-1 Johoku, Hamamatsu, Shizuoka, 432-8561, Japan.

Kazuhiro Takeda (K)

Applied Chemistry and Biochemical Engineering Course Department of Engineering, Graduate School of Integrated Science and Technology, Shizuoka University, 3-5-1 Johoku, Hamamatsu, Shizuoka, 432-8561, Japan.

Nobuyuki Mase (N)

Applied Chemistry and Biochemical Engineering Course Department of Engineering, Graduate School of Integrated Science and Technology, Shizuoka University, 3-5-1 Johoku, Hamamatsu, Shizuoka, 432-8561, Japan.

Classifications MeSH