Genetic variants of resistin and its plasma levels: Association with obesity and dyslipidemia related to type 2 diabetes susceptibility.
Genotype-phenotype association
Haplotype
Linkage disequilibrium
Lipids
Single nucleotide polymorphism
Journal
Genomics
ISSN: 1089-8646
Titre abrégé: Genomics
Pays: United States
ID NLM: 8800135
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
02
02
2018
revised:
25
06
2018
accepted:
26
06
2018
pubmed:
4
7
2018
medline:
31
12
2019
entrez:
4
7
2018
Statut:
ppublish
Résumé
Resistin, an adipokine, is involved in obesity and Type 2 Diabetes (T2D). The current study evaluates the association between RETN polymorphisms (-638 G/A, -420C/G & -358 G/A) and the risk towards T2D. Controls and T2D patients were enrolled from Gujarat, India. Polymorphisms of RETN were genotyped by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism. For the genotype-phenotype correlation analysis Fasting Blood Glucose (FBG), Body Mass Index (BMI) and plasma lipid profile were used. Plasma levels of resistin were assayed by ELISA. Our study suggests an association of RETN -420C/G polymorphism with T2D risk. The CC genotype of RETN -420C/G polymorphism was found to be associated with FBG, BMI, and total cholesterol. Plasma resistin levels were found to be significantly increased in diabetic patients as compared to controls. Our findings suggest -420C/G polymorphism of RETN as an important factor which could pose a powerful risk towards T2D susceptibility.
Identifiants
pubmed: 29969661
pii: S0888-7543(18)30073-9
doi: 10.1016/j.ygeno.2018.06.005
pii:
doi:
Substances chimiques
Blood Glucose
0
Resistin
0
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
980-985Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.