No evidence in support of a prodromal respiratory control signature in the TgF344-AD rat model of Alzheimer's disease.

Alzheimer Disease / metabolism Amyloid beta-Protein Precursor / metabolism Anesthesia, General Animals Apnea / physiopathology Brain Stem / metabolism Diaphragm / physiopathology Disease Models, Animal Electromyography Presenilin-1 / metabolism Prodromal Symptoms Rats Rats, Inbred F344 Rats, Transgenic Reflex / physiology Respiration Tongue / physiopathology Vagotomy
Amyloid precursor protein Neuroinflammation Presenilin-1 Pulmonary chemoreflex Respiratory behaviour

Journal

Respiratory physiology & neurobiology
ISSN: 1878-1519
Titre abrégé: Respir Physiol Neurobiol
Pays: Netherlands
ID NLM: 101140022

Informations de publication

Date de publication:
07 2019
Historique:
received: 29 03 2018
revised: 25 05 2018
accepted: 29 06 2018
pubmed: 4 7 2018
medline: 3 4 2020
entrez: 4 7 2018
Statut: ppublish

Résumé

Alzheimer's disease (AD) is a progressive neurodegenerative condition disturbing major brain networks, including those pivotal to the motor control of breathing. The aim of this study was to examine respiratory control in the TgF344-AD transgenic rat model of AD. At 8-11 months of age, basal minute ventilation and ventilatory responsiveness to chemostimulation were equivalent in conscious wild-type (WT) and TgF344-AD rats. Under urethane anesthesia, basal diaphragm and genioglossus EMG activities were similar in WT and TgF344-AD rats. The duration of phenylbiguanide-induced apnoea was significantly shorter in TgF344-AD rats compared with WT. Following bilateral cervical vagotomy, diaphragm and genioglossus EMG responsiveness to chemostimulation were intact in TgF344-AD rats. Amyloid precursor protein C-terminal fragments were elevated in the TgF344-AD brainstem, in the absence of amyloid-β accumulation or alterations in tau phosphorylation. Brainstem pro-inflammatory cytokine concentrations were not increased in TgF344-AD rats. We conclude that neural control of breathing is preserved in TgF344-AD rats at this stage of the disease.

Identifiants

DOI: 10.1016/j.resp.2018.06.014 PMID: 29969703
pubmed: 29969703
pii: S1569-9048(18)30104-6
doi: 10.1016/j.resp.2018.06.014
pii:
doi:

Substances chimiques

Amyloid beta-Protein Precursor 0
Presenilin-1 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

55-67

Informations de copyright

Copyright © 2018 Elsevier B.V. All rights reserved.

Auteurs

Eric F Lucking (EF)

Department of Physiology, School of Medicine, College of Medicine & Health, University College Cork, Cork, Ireland.

Kevin H Murphy (KH)

Department of Physiology, School of Medicine, College of Medicine & Health, University College Cork, Cork, Ireland.

David P Burns (DP)

Department of Physiology, School of Medicine, College of Medicine & Health, University College Cork, Cork, Ireland.

Anirudh V Jaisimha (AV)

Department of Pharmacology and Therapeutics, School of Medicine, College of Medicine & Health, University College Cork, Cork, Ireland.

Kevin J Barry-Murphy (KJ)

Department of Physiology, School of Medicine, College of Medicine & Health, University College Cork, Cork, Ireland.

Pardeep Dhaliwal (P)

Department of Physiology, School of Medicine, College of Medicine & Health, University College Cork, Cork, Ireland.

Barry Boland (B)

Department of Pharmacology and Therapeutics, School of Medicine, College of Medicine & Health, University College Cork, Cork, Ireland.

Mark G Rae (MG)

Department of Physiology, School of Medicine, College of Medicine & Health, University College Cork, Cork, Ireland.

Ken D O'Halloran (KD)

Department of Physiology, School of Medicine, College of Medicine & Health, University College Cork, Cork, Ireland. Electronic address: k.ohalloran@ucc.ie.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › No evidence in support of a prodromal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines sécrétoires inhibitrices de protéinases › Protéase nexines › Précurseur de la protéine bêta-amyloïde › No evidence in support of a prodromal...
questionsmedicales.fr › Anesthésie et analgésie › Anesthésie › Anesthésie générale › No evidence in support of a prodromal...
questionsmedicales.fr › Eucaryotes › Animaux › No evidence in support of a prodromal...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Apnée › No evidence in support of a prodromal...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › No evidence in support of a prodromal...
questionsmedicales.fr › Appareil locomoteur › Muscles respiratoires › Muscle diaphragme › No evidence in support of a prodromal...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › No evidence in support of a prodromal...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Myographie › Électromyographie › No evidence in support of a prodromal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Présénilines › Préséniline-1 › No evidence in support of a prodromal...
questionsmedicales.fr › Diagnostic › Symptômes prodromiques › No evidence in support of a prodromal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › No evidence in support of a prodromal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Lignées consanguines de rats › Rats de lignée F344 › No evidence in support of a prodromal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rats transgéniques › No evidence in support of a prodromal...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Réflexe › No evidence in support of a prodromal...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques respiratoires › Respiration › No evidence in support of a prodromal...
questionsmedicales.fr › Système stomatognathique › Bouche › Langue › No evidence in support of a prodromal...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de neurochirurgie › Dénervation › Dénervation autonome › Parasympathectomie › Vagotomie › No evidence in support of a prodromal...