Lysophosphatidylcholine-induced cytotoxicity and protection by heparin in mouse brain bEND.3 endothelial cells.

Animals Apoptosis / drug effects Atherosclerosis / pathology Brain / drug effects Calcium / metabolism Caspase 3 / metabolism Cells, Cultured Endothelial Cells / drug effects Endothelium, Vascular / cytology Heparin / pharmacology Lipoproteins, LDL / metabolism Lysophosphatidylcholines / toxicity Membrane Potential, Mitochondrial / drug effects Mice Reactive Oxygen Species / metabolism p38 Mitogen-Activated Protein Kinases / metabolism

apoptosis atherosclerosis endothelial cells heparin lysophosphatidylcholine

Journal

Fundamental & clinical pharmacology

ISSN: 1472-8206

Titre abrégé: Fundam Clin Pharmacol

Pays: England

ID NLM: 8710411

Informations de publication

Date de publication:
Feb 2019

Historique:

received: 29 10 2017

revised: 28 06 2018

accepted: 03 07 2018

pubmed: 6 7 2018

medline: 13 4 2019

entrez: 6 7 2018

Statut: ppublish

Résumé

A pathological feature in atherosclerosis is the dysfunction and death of vascular endothelial cells (EC). Oxidized low-density lipoprotein (LDL), known to accumulate in the atherosclerotic arterial walls, impairs endothelium-dependent relaxation and causes EC apoptosis. A major bioactive ingredient of the oxidized LDL is lysophosphatidylcholine (LPC), which at higher concentrations causes apoptosis and necrosis in various EC. There is hitherto no report on LPC-induced cytotoxicity in brain EC. In this work, we found that LPC caused cytosolic Ca

Identifiants

DOI: 10.1111/fcp.12399 PMID: 29974515

pubmed: 29974515

doi: 10.1111/fcp.12399

doi:

Substances chimiques

Lipoproteins, LDL 0

Lysophosphatidylcholines 0

Reactive Oxygen Species 0

oxidized low density lipoprotein 0

Heparin 9005-49-6

p38 Mitogen-Activated Protein Kinases EC 2.7.11.24

Caspase 3 EC 3.4.22.-

Calcium SY7Q814VUP

Types de publication

Journal Article

Langues

eng

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