Aberrant Wnt Signaling Pathway in the Hematopoietic Stem/Progenitor Compartment in Experimental Leukemic Animal.
ENU
Leukemia
N-Cadherin
Wnt signaling
Wnt3a
Wnt5a
Journal
Journal of cell communication and signaling
ISSN: 1873-9601
Titre abrégé: J Cell Commun Signal
Pays: Netherlands
ID NLM: 101308338
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
08
03
2018
accepted:
22
05
2018
pubmed:
7
7
2018
medline:
7
7
2018
entrez:
7
7
2018
Statut:
ppublish
Résumé
The evolutionarily conserved Wnt signaling pathway regulates physiological hematopoiesis, a process of formation of blood cells and has been shown to play crucial role in the development of both myeloid and lymphoid malignancies. The Wnt signaling pathway can be broadly divided into canonical and non-canonical pathways. In the present study, we investigated the pathobiology of leukemia by studying the expression profile of Wnt proteins, receptors, key signaling intermediates and endogenous Wnt antagonist involved in canonical and non-canonical pathways in the bone marrow (BM) hematopoietic stem/progenitor cell (HSPC) compartment of experimental leukemic mice. Cell adhesion molecule N-Cadherin and leukemic BM microenvironment with reference to Wnt were also studied. We used ENU, a potent carcinogen, to induce leukemia in wild type Swiss albino mice and malignant transformation was cofirmed by peripheral blood and BM studies. Flow cytometric expression analysis revealed profound up-regulation of canonical Wnt3a/β-catenin/CyclinD1 signaling axis along with N-Cadherin whereas down-regulation of non-canonical Wnt5a/Ca
Identifiants
pubmed: 29978347
doi: 10.1007/s12079-018-0470-6
pii: 10.1007/s12079-018-0470-6
pmc: PMC6381377
doi:
Types de publication
Journal Article
Langues
eng
Pagination
39-52Subventions
Organisme : INSPIRE Fellowship, Dept. of Science and Technology, Govt. of India
ID : DST/INSPIRE Fellowship/2013/283(IF130354)
Organisme : Council for Scientific and Industrial Research (CSIR), Govt. of India
ID : No. 37(1429)/10/EMRII
Références
Proc Natl Acad Sci U S A. 1999 May 11;96(10):5522-7
pubmed: 10318916
J Biol Chem. 2001 Jan 19;276(3):1735-41
pubmed: 11013247
Immunol Lett. 2001 Apr 2;76(3):145-52
pubmed: 11306141
Mol Cell Biol. 2003 Jan;23(1):131-9
pubmed: 12482967
Curr Opin Cell Biol. 2003 Apr;15(2):158-63
pubmed: 12648671
J Cell Biol. 2003 Sep 1;162(5):899-908
pubmed: 12952940
Cancer Cell. 2003 Nov;4(5):349-60
pubmed: 14667502
PLoS Biol. 2006 Apr;4(4):e115
pubmed: 16602827
Leukemia. 2006 Jul;20(7):1211-6
pubmed: 16688229
Leukemia. 2007 Nov;21(11):2264-70
pubmed: 17611554
Blood. 2007 Dec 1;110(12):4130-2
pubmed: 18024799
Cell Stem Cell. 2008 Mar 6;2(3):274-83
pubmed: 18371452
Blood. 2009 Jul 30;114(5):937-51
pubmed: 19357394
Dev Dyn. 2010 Jan;239(1):1-15
pubmed: 19530173
J Biol Chem. 2009 Oct 30;284(44):30167-76
pubmed: 19720827
Cancer Sci. 2010 Feb;101(2):425-32
pubmed: 19874313
J Stem Cells. 2009;4(3):179-89
pubmed: 20232602
Science. 2010 Mar 26;327(5973):1650-3
pubmed: 20339075
Bone. 2011 Jan;48(1):115-20
pubmed: 20541047
Int J Mol Med. 2011 Jan;27(1):63-9
pubmed: 21069266
Chin J Cancer. 2010 Dec;29(12):969-79
pubmed: 21114916
Blood. 2011 Sep 1;118(9):2420-9
pubmed: 21652676
Acta Biochim Biophys Sin (Shanghai). 2011 Oct;43(10):745-56
pubmed: 21903638
PLoS One. 2011;6(11):e27308
pubmed: 22073312
Leukemia. 2012 Mar;26(3):414-21
pubmed: 22173215
Cold Spring Harb Perspect Biol. 2012 May 01;4(5):null
pubmed: 22438566
Clin Epigenetics. 2011 Aug;2(2):63-76
pubmed: 22704330
Blood. 2013 Mar 7;121(10):1824-38
pubmed: 23299311
Cold Spring Harb Perspect Biol. 2013 Feb 01;5(2):null
pubmed: 23378582
Blood. 2013 Jun 20;121(25):5045-54
pubmed: 23660959
Carcinogenesis. 2013 Nov;34(11):2629-38
pubmed: 23764752
Mol Cell Biochem. 2013 Oct;382(1-2):293-306
pubmed: 23861106
Blood Cells Mol Dis. 2013 Dec;51(4):264-70
pubmed: 23927968
Nature. 2013 Nov 21;503(7476):392-6
pubmed: 24141946
Trends Immunol. 2014 Jan;35(1):32-7
pubmed: 24210164
Ann N Y Acad Sci. 2014 Mar;1310:7-31
pubmed: 24495159
Ann N Y Acad Sci. 2014 Mar;1310:32-43
pubmed: 24611828
Leuk Res. 2014 May;38(5):632-7
pubmed: 24703771
J Cereb Blood Flow Metab. 2014 Aug;34(8):1258-69
pubmed: 24896565
PLoS One. 2014 Jul 14;9(7):e101800
pubmed: 25019931
BMC Cancer. 2014 Nov 27;14:886
pubmed: 25428027
Exp Cell Res. 2014 Dec 10;329(2):227-33
pubmed: 25447318
Mol Cell Biochem. 2015 Mar;401(1-2):115-31
pubmed: 25472879
Environ Toxicol. 2016 Oct;31(10):1163-75
pubmed: 25846497
Turk J Haematol. 2015 Jun;32(2):127-35
pubmed: 26316480
Exp Cell Res. 2016 Jan 1;340(1):91-101
pubmed: 26658517
Anat Rec (Hoboken). 2016 Jul;299(7):990-8
pubmed: 27064800
Leuk Res. 2016 Aug;47:70-7
pubmed: 27280487
Oncogene. 2017 Mar;36(11):1461-1473
pubmed: 27617575
Mol Cell Biochem. 2016 Nov;422(1-2):121-134
pubmed: 27632389
Chem Biol Interact. 2016 Dec 25;260:176-185
pubmed: 27725143
Zhonghua Kou Qiang Yi Xue Za Zhi. 2016 Nov 9;51(11):673-679
pubmed: 27806760
Exp Ther Med. 2016 Dec;12(6):4128-4134
pubmed: 28101190
Front Immunol. 2017 Feb 09;8:106
pubmed: 28232835
Oncol Rep. 2017 May;37(5):2663-2671
pubmed: 28440495
Crit Rev Biochem Mol Biol. 2017 Aug;52(4):414-424
pubmed: 28508727
Biol Trace Elem Res. 2018 Feb;181(2):304-313
pubmed: 28516389