Klotho at the Edge of Alzheimer's Disease and Senile Depression.
Aging
Alzheimer’s disease
Depression
KL
Klotho
Late-life major depressive disorder
MDD
Journal
Molecular neurobiology
ISSN: 1559-1182
Titre abrégé: Mol Neurobiol
Pays: United States
ID NLM: 8900963
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
05
04
2018
accepted:
26
06
2018
pubmed:
7
7
2018
medline:
2
7
2019
entrez:
7
7
2018
Statut:
ppublish
Résumé
Klotho, encoded by the KL gene, is a single-pass transmembrane protein and a circulating factor that plays a key role in cellular metabolism and body homeostasis and has been associated with age-related diseases. Alterations of this protein seem to influence the development of serotonergic neurons and could play a role in major depression in the elderly. Pretreatment of neurons with Klotho protein can avoid neuronal injury related to the toxic amyloid-β and glutamate, centrally related to the pathogenesis of Alzheimer's disease (AD), in order that Klotho protein could play a neuroprotective role in AD patients. Late-life depression, mild cognitive impairment, and dementia are different nosological entities but share common neurobiological facets and could represent a clinical continuum. Enhancement of Klotho levels in the early stages of the disease could represent a therapeutic strategy to prevent further deterioration and to ameliorate the outcome of elderly AD patients with or without major depression.
Identifiants
pubmed: 29978424
doi: 10.1007/s12035-018-1200-z
pii: 10.1007/s12035-018-1200-z
doi:
Substances chimiques
Glucuronidase
EC 3.2.1.31
Klotho Proteins
EC 3.2.1.31
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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