Inhibition of macrophage inflammatory protein-1β improves endothelial progenitor cell function and ischemia-induced angiogenesis in diabetes.
Angiogenesis
Diabetes mellitus
Endothelial progenitor cell
Inflammation
Ischemia
Macrophage inflammatory protein-1β
Journal
Angiogenesis
ISSN: 1573-7209
Titre abrégé: Angiogenesis
Pays: Germany
ID NLM: 9814575
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
20
03
2018
accepted:
03
07
2018
pubmed:
11
7
2018
medline:
27
3
2020
entrez:
11
7
2018
Statut:
ppublish
Résumé
Systemic inflammation might contribute to the impairment of neovasculogenesis and endothelial progenitor cell (EPC) function in clinical diabetes mellitus (DM). Macrophage inflammatory protein-1β (MIP-1β) is an inflammatory chemokine that may be up-regulated in clinical DM. Its role in diabetic vasculopathy was not clarified. This study aimed to investigate the role of MIP-1β in human EPCs and in neovasculogenesis in different diabetic animal models with hindlimb ischemia. EPCs chamber assay and in vitro tube formation assay were used to estimate the degree of EPC migration and tube formation abilities. Lepr
Identifiants
pubmed: 29987448
doi: 10.1007/s10456-018-9636-3
pii: 10.1007/s10456-018-9636-3
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
Ccl4 protein, mouse
0
Chemokine CCL4
0
MAPKAP1 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
53-65Subventions
Organisme : Taipei Veterans General Hospital, Taipei, Taiwan
ID : V105E18-004-MY3, V105C-117, and V104C-101
Pays : International