A preclinical evaluation of a programmable CNT membrane device for transdermal nicotine delivery in hairless Guinea pigs.

Administration, Cutaneous Animals Cotinine / blood Guinea Pigs Membranes, Artificial Microdialysis Nanotubes, Carbon Nicotine / administration & dosage
Addiction treatment CNT membrane Microdialysis Nicotine Pharmacokinetic Programmable device Transdermal drug delivery

Journal

Journal of controlled release : official journal of the Controlled Release Society
ISSN: 1873-4995
Titre abrégé: J Control Release
Pays: Netherlands
ID NLM: 8607908

Informations de publication

Date de publication:
10 01 2019
Historique:
received: 19 06 2017
revised: 30 04 2018
accepted: 02 07 2018
pubmed: 11 7 2018
medline: 20 3 2020
entrez: 11 7 2018
Statut: ppublish

Résumé

Nicotine replacement therapy in the form of transdermal nicotine patches and nicotine gums combined with behavioral counseling still has a low smoking cessation rate of 25%. A promising approach to smoking cessation is to remotely program variable transdermal nicotine delivery rates, with inputs from counselor and patient through a smartphone counseling application. A switchable carbon nanotube (CNT) membrane device has been developed for transdermal nicotine delivery that can be programmed to deliver variable doses matching those of nicotine patches (7, 14 and 21 mg/24 h) and nicotine gums (2 mg /4 mg). The performance of switchable devices was evaluated in vitro on flow-cell geometry and in vivo on the skin of hairless guinea pig (HGP). In vitro, CNT membrane devices successfully switched between therapeutically useful nicotine fluxes of 1.3-1.8 μmoles/cm

Identifiants

DOI: 10.1016/j.jconrel.2018.07.003 PMID: 29990525
pubmed: 29990525
pii: S0168-3659(18)30397-3
doi: 10.1016/j.jconrel.2018.07.003
pii:
doi:

Substances chimiques

Membranes, Artificial 0
Nanotubes, Carbon 0
Nicotine 6M3C89ZY6R
Cotinine K5161X06LL

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

135-143

Subventions

Organisme : NIDA NIH HHS
ID : R01 DA018822
Pays : United States

Informations de copyright

Copyright © 2018. Published by Elsevier B.V.

Auteurs

Gaurav Kumar Gulati (GK)

Materials Science and Engineering Department, University of Washington, Seattle, WA, USA. Electronic address: ggulati@uw.edu.

Lily Rachel Berger (LR)

Materials Science and Engineering Department, University of Washington, Seattle, WA, USA. Electronic address: lrberger@uw.edu.

Bruce Jackson Hinds (BJ)

Materials Science and Engineering Department, University of Washington, Seattle, WA, USA. Electronic address: bjhinds@uw.edu.

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie topique › Administration par voie cutanée › A preclinical evaluation of a programmable CNT...
questionsmedicales.fr › Eucaryotes › Animaux › A preclinical evaluation of a programmable CNT...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrrolidines › Pyrrolidones › Cotinine › A preclinical evaluation of a programmable CNT...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Cochons d'Inde › A preclinical evaluation of a programmable CNT...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomimétiques › Membrane artificielle › A preclinical evaluation of a programmable CNT...
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questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanotubes › Nanotubes de carbone › A preclinical evaluation of a programmable CNT...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Nicotine › A preclinical evaluation of a programmable CNT...