Pharmacokinetics of Riluzole in Beagle Dogs.

Administration, Oral Animals Area Under Curve Chromatography, Liquid / methods Dogs Female Male Plasma / metabolism Riluzole / blood Spinal Cord Injuries / blood Tandem Mass Spectrometry / methods

Journal

Drug research
ISSN: 2194-9387
Titre abrégé: Drug Res (Stuttg)
Pays: Germany
ID NLM: 101602406

Informations de publication

Date de publication:
Jan 2019
Historique:
pubmed: 11 7 2018
medline: 4 4 2019
entrez: 11 7 2018
Statut: ppublish

Résumé

Riluzole is a benzothiazole anticonvulsant used in the treatment of patients with amyotrophic lateral sclerosis and it is being investigated for clinical use in patients with spinal cord injury. The present study evaluated the pharmacokinetics of riluzole in beagle dogs after oral dose administration. The oral doses (1.5, 5, 15 and 50 mg/kg) of riluzole were administered to beagle dogs and blood samples were collected from 0 h to 24 h post drug administration. Riluzole was quantified by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). The method was sensitive, precise, accurate and selective to riluzole quantification in plasma of beagle dogs. The pharmacokinetics following oral administration was linear from 1.5 to 15 mg/kg and the t The riluzole pharmacokinetics was linear up to 15 mg/kg and had a significantlyshorter t

Sections du résumé

BACKGROUND BACKGROUND
Riluzole is a benzothiazole anticonvulsant used in the treatment of patients with amyotrophic lateral sclerosis and it is being investigated for clinical use in patients with spinal cord injury. The present study evaluated the pharmacokinetics of riluzole in beagle dogs after oral dose administration.
METHODS METHODS
The oral doses (1.5, 5, 15 and 50 mg/kg) of riluzole were administered to beagle dogs and blood samples were collected from 0 h to 24 h post drug administration. Riluzole was quantified by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS).
RESULTS RESULTS
The method was sensitive, precise, accurate and selective to riluzole quantification in plasma of beagle dogs. The pharmacokinetics following oral administration was linear from 1.5 to 15 mg/kg and the t
CONCLUSION CONCLUSIONS
The riluzole pharmacokinetics was linear up to 15 mg/kg and had a significantlyshorter t

Identifiants

DOI: 10.1055/a-0645-1248 PMID: 29991087
pubmed: 29991087
doi: 10.1055/a-0645-1248
doi:

Substances chimiques

Riluzole 7LJ087RS6F

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

40-45

Informations de copyright

© Georg Thieme Verlag KG Stuttgart · New York.

Déclaration de conflit d'intérêts

The authors have no conflict of interests.

Auteurs

Ana P L Perdigão (APL)

Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil.

Natalícia de Jesus Antunes (NJ)

Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil.

Lucas T Juni (LT)

Faculty of Medicine, Mogi das Cruzes University, Mogi das Cruzes, SP, Brazil.

Noedi L de Freitas (NL)

Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil.
Department of Pharmacology, Faculty of Medical Sciences, Brazil University, São Paulo, SP, Brazil.

Julio Rojas-Moscoso (J)

Department of Pharmacology, Faculty of Medical Sciences, Brazil University, São Paulo, SP, Brazil.

Sílvia V M Corrêa (SVM)

Anhembi Morumbi University, São Paulo, SP, Brazil.

Ronaldo C da Costa (RC)

The Ohio State University, Columbus, OH, USA.

Ronilson A Moreno (RA)

Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil.

Gustavo D Mendes (GD)

Faculty of Medicine, São Leopoldo Mandic (SLMANDIC), Campinas, SP, Brazil.
Department of Pharmacology, Faculty of Medicine, Metropolitan University of Santos, Santos, SP, Brazil.

Gilberto De Nucci (G)

Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil.
Faculty of Medicine, Mogi das Cruzes University, Mogi das Cruzes, SP, Brazil.
Department of Pharmacology, Faculty of Medical Sciences, Brazil University, São Paulo, SP, Brazil.

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie orale › Pharmacokinetics of Riluzole in Beagle Dogs.
questionsmedicales.fr › Eucaryotes › Animaux › Pharmacokinetics of Riluzole in Beagle Dogs.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Aire sous la courbe › Pharmacokinetics of Riluzole in Beagle Dogs.
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Pharmacokinetics of Riluzole in Beagle Dogs.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Pinnipedia › Canidae › Chiens › Pharmacokinetics of Riluzole in Beagle Dogs.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Sang › Plasma sanguin › Pharmacokinetics of Riluzole in Beagle Dogs.
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzothiazoles › Riluzole › Pharmacokinetics of Riluzole in Beagle Dogs.
questionsmedicales.fr › Plaies et blessures › Traumatismes de la moelle épinière › Pharmacokinetics of Riluzole in Beagle Dogs.
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › Pharmacokinetics of Riluzole in Beagle Dogs.