Intestinal macrophages and their interaction with the enteric nervous system in health and inflammatory bowel disease.
cholinergic anti-inflammatory pathway
enteric nervous system
inflammatory bowel disease
macrophages
vagal nerve stimulation
Journal
Acta physiologica (Oxford, England)
ISSN: 1748-1716
Titre abrégé: Acta Physiol (Oxf)
Pays: England
ID NLM: 101262545
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
25
01
2018
revised:
07
07
2018
accepted:
09
07
2018
pubmed:
13
7
2018
medline:
4
6
2020
entrez:
13
7
2018
Statut:
ppublish
Résumé
Over the past decades, there has been an increasing understanding of cellular and molecular mechanisms that mediate modulation of the immune system by the autonomic nervous system. The discovery that vagal nerve stimulation (VNS) attenuates endotoxin-induced experimental sepsis paved the way for further studies investigating neuro-immune interaction. In particular, great attention is now given to intestinal macrophages: several studies report the existence of both intrinsic and extrinsic neural mechanisms by which intestinal immune homoeostasis can be regulated in different layers of the intestine, mainly by affecting macrophage activation through neurotransmitter release. Given the important role of inflammation in numerous disease processes, such as inflammatory bowel disease (IBD), cholinergic anti-inflammatory mechanisms are under intense investigation both from a basic and clinical science perspective in immune-mediated diseases such as IBD. This review discusses recent insights on the cross-talk between enteric neurons and the immune system, especially focusing on macrophages, and provides an overview of basic and translational aspects of the cholinergic anti-inflammatory response as therapeutic alternative to reinstall immune homoeostasis in intestinal chronic inflammation.
Identifiants
pubmed: 29998613
doi: 10.1111/apha.13163
pmc: PMC6519157
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13163Subventions
Organisme : European Research Council
ID : ERC-2013-Adg: 340101 Cholstim
Pays : International
Informations de copyright
© 2018 The Authors. Acta Physiologica published by John Wiley & Sons Ltd on behalf of Scandinavian Physiological Society.
Références
Science. 2011 Oct 7;334(6052):98-101
pubmed: 21921156
J Am Osteopath Assoc. 2005 Mar;105(3):145-58
pubmed: 15863734
Neurology. 2015 Mar 24;84(12):1249-53
pubmed: 25713002
Brain Stimul. 2015 May-Jun;8(3):624-36
pubmed: 25573069
Brain Stimul. 2014 Nov-Dec;7(6):914-6
pubmed: 25263316
Neurogastroenterol Motil. 2013 Aug;25(8):e540-9
pubmed: 23711101
Gastroenterology. 2006 Oct;131(4):1122-30
pubmed: 17030182
Immunity. 2011 Feb 25;34(2):237-46
pubmed: 21333554
J Intern Med. 2011 Jan;269(1):45-53
pubmed: 21158977
Br J Pharmacol. 2010 May;160(2):322-33
pubmed: 20423343
Neurogastroenterol Motil. 2016 Apr;28(4):592-8
pubmed: 26728182
J Leukoc Biol. 2014 Mar;95(3):531-41
pubmed: 24212097
Nat Immunol. 2014 Oct;15(10):929-937
pubmed: 25151491
Front Immunol. 2017 Nov 02;8:1452
pubmed: 29163522
Psychoneuroendocrinology. 2010 Jun;35(5):653-62
pubmed: 19910123
Mol Med. 2009 Jul-Aug;15(7-8):195-202
pubmed: 19593403
Handb Exp Pharmacol. 2017;239:247-267
pubmed: 28035531
Am J Physiol Gastrointest Liver Physiol. 2014 Nov 15;307(10):G968-78
pubmed: 25258409
Mucosal Immunol. 2013 May;6(3):498-510
pubmed: 22990622
J Exp Med. 2012 Jan 16;209(1):139-55
pubmed: 22231304
PLoS One. 2018 May 23;13(5):e0197487
pubmed: 29791477
J Exp Med. 2006 Jul 10;203(7):1623-8
pubmed: 16785311
Nat Immunol. 2005 Aug;6(8):844-51
pubmed: 16025117
Auton Neurosci. 2000 Dec 20;85(1-3):141-7
pubmed: 11189021
Gastroenterology. 2005 Jul;129(1):50-65
pubmed: 16012934
Am J Physiol Gastrointest Liver Physiol. 2007 Sep;293(3):G560-7
pubmed: 17585014
Gut. 2015 Apr;64(4):611-7
pubmed: 24870622
Science. 2005 Jan 14;307(5707):254-8
pubmed: 15653504
Auton Neurosci. 2003 Apr 30;105(1):16-24
pubmed: 12742187
Gut. 2006 Nov;55(11):1640-9
pubmed: 17047110
Arthritis Rheum. 2008 Sep;58(9):2919-21
pubmed: 18759350
PLoS One. 2013 Nov 01;8(11):e79264
pubmed: 24223920
Nature. 2007 Jul 26;448(7152):427-34
pubmed: 17653185
Am J Physiol. 1991 Jan;260(1 Pt 2):R200-7
pubmed: 1992820
Ann N Y Acad Sci. 1998 May 1;840:599-607
pubmed: 9629287
Adv Exp Med Biol. 2014;817:39-71
pubmed: 24997029
Acta Otolaryngol. 2017 Apr;137(4):426-431
pubmed: 28084177
PLoS One. 2014 Sep 10;9(9):e105328
pubmed: 25207649
J Immunol. 2010 Jun 15;184(12):6843-54
pubmed: 20483766
Cell. 2016 Jan 28;164(3):378-91
pubmed: 26777404
J Gastroenterol. 2018 Jan;53(1):95-106
pubmed: 28852861
J Clin Neurophysiol. 2010 Apr;27(2):130-8
pubmed: 20505378
Nicotine Tob Res. 2017 Apr 01;19(4):460-468
pubmed: 27639096
Nature. 2002 Dec 19-26;420(6917):853-9
pubmed: 12490958
Scand J Gastroenterol. 1991 Apr;26(4):361-6
pubmed: 2034989
Acta Physiol (Oxf). 2019 Mar;225(3):e13163
pubmed: 29998613
Auton Neurosci. 2011 Feb 24;160(1-2):82-9
pubmed: 21071287
Immunity. 2012 Dec 14;37(6):1076-90
pubmed: 23219392
Mol Med. 2016 Oct;22:464-476
pubmed: 27341335
Gastroenterology. 2009 Jun;136(7):2280-2288.e1-4
pubmed: 19272381
Neurogastroenterol Motil. 2012 Feb;24(2):191-200, e93
pubmed: 22118533
Gut. 2014 Jun;63(6):938-48
pubmed: 23929694
Neurosci Biobehav Rev. 2005 May;29(3):493-500
pubmed: 15820552
Annu Rev Immunol. 2010;28:573-621
pubmed: 20192811
Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8284-9
pubmed: 27382171
PLoS One. 2013 Aug 02;8(8):e69424
pubmed: 23936328
Br J Anaesth. 2011 Oct;107(4):559-66
pubmed: 21771746
PLoS One. 2014 Oct 08;9(10):e109272
pubmed: 25295619
Nat Commun. 2015 Jul 21;6:7802
pubmed: 26193821
J Comp Neurol. 1990 Nov 1;301(1):65-79
pubmed: 1706359
World J Gastroenterol. 2006 Aug 14;12(30):4807-12
pubmed: 16937461
Am J Physiol Regul Integr Comp Physiol. 2009 Oct;297(4):R1118-26
pubmed: 19675277
Front Immunol. 2015 Nov 20;6:590
pubmed: 26635804
Nature. 2003 Jan 23;421(6921):384-8
pubmed: 12508119
Gastroenterology. 2007 Oct;133(4):1219-28
pubmed: 17919496
Neurogastroenterol Motil. 2016 Jun;28(6):948-53
pubmed: 26920654
J Immunol. 2017 Jan 1;198(1):335-343
pubmed: 27895168
Immunol Rev. 2014 Jul;260(1):102-17
pubmed: 24942685
J Mol Med (Berl). 2017 Feb;95(2):221-233
pubmed: 27709266
Brain Behav Immun. 2009 Jan;23(1):41-5
pubmed: 18639629
Cell. 2014 Jul 17;158(2):300-313
pubmed: 25036630
Cell. 2014 May 8;157(4):832-44
pubmed: 24792964
Mucosal Immunol. 2014 Mar;7(2):335-47
pubmed: 23881354
Inflamm Bowel Dis. 2011 Jul;17(7):1474-89
pubmed: 21246669
Neuromodulation. 2016 Apr;19(3):283-90
pubmed: 26990318
Brain Behav Immun. 2005 Jul;19(4):334-44
pubmed: 15944073
PLoS One. 2014 Jan 29;9(1):e87785
pubmed: 24489965
Clin Anat. 2002 Jan;15(1):35-7
pubmed: 11835542
Nat Rev Immunol. 2009 Jun;9(6):418-28
pubmed: 19461672