Pharmacogenomics of Vincristine-Induced Peripheral Neuropathy Implicates Pharmacokinetic and Inherited Neuropathy Genes.
Antineoplastic Agents, Phytogenic
/ pharmacokinetics
Child
Child, Preschool
Computational Biology
Female
Humans
Male
Microtubule-Associated Proteins
/ genetics
Multidrug Resistance-Associated Proteins
/ genetics
Peripheral Nervous System Diseases
/ chemically induced
Pharmacogenetics
Tissue Distribution
Vincristine
/ pharmacokinetics
Journal
Clinical pharmacology and therapeutics
ISSN: 1532-6535
Titre abrégé: Clin Pharmacol Ther
Pays: United States
ID NLM: 0372741
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
26
04
2018
accepted:
03
07
2018
pubmed:
13
7
2018
medline:
14
11
2019
entrez:
13
7
2018
Statut:
ppublish
Résumé
Vincristine is an effective chemotherapeutic drug for various cancers, including acute lymphoblastic leukemia (ALL). Unfortunately, clinical utility is restricted by dose-limiting vincristine-induced peripheral neuropathies (VIPN). We sought to determine the association of VIPN with a recently identified risk variant, CEP72 rs924607, and drug absorption, distribution, metabolism, and excretion (ADME) gene variants in pediatric ALL. This was followed by a meta-analysis of pharmacogenomic data from over 500 patients. CEP72 rs924607 was significantly associated with VIPN (P = 0.02; odds ratio (OR) = 3.4). ADME analyses identified associations between VIPN and ABCC1 rs3784867 (P = 5.34 × 10
Identifiants
pubmed: 29999516
doi: 10.1002/cpt.1179
pmc: PMC6519044
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
CEP72 protein, human
0
Microtubule-Associated Proteins
0
Multidrug Resistance-Associated Proteins
0
Vincristine
5J49Q6B70F
multidrug resistance-associated protein 1
Y49M64GZ4Q
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
402-410Subventions
Organisme : CIHR
ID : CRI-88362
Pays : Canada
Organisme : CIHR
ID : TD1 137714
Pays : Canada
Organisme : CIHR
ID : TD2 117588
Pays : Canada
Investigateurs
Henk Visscher
(H)
Folefac Aminkeng
(F)
Michelle Higginson
(M)
Nasim Massah
(N)
Fudan Miao
(F)
Amit Bhavsar
(A)
Jong Lee
(J)
Tessa Bendyshe-Walton
(T)
Reo Tanoshima
(R)
David Johnson
(D)
Carnation Zhuwaki
(C)
Nick Honcharik
(N)
Geert't Jong
(G)
Sara Israels
(S)
Michelle Staub
(M)
Michael Rieder
(M)
Lauren Faught
(L)
Shinya Ito
(S)
Paul Nathan
(P)
Smita Karande
(S)
Régis Vaillancourt
(R)
Donna Johnston
(D)
Kimmy Nguyen
(K)
Jean-François Bussières
(JF)
Denis Lebel
(D)
Jennifer Jean-Louis
(J)
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2018 The Authors Clinical Pharmacology & Therapeutics published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.
Références
Lancet Oncol. 2010 Nov;11(11):1057-65
pubmed: 20864405
Nucleic Acids Res. 2012 Jan;40(Database issue):D930-4
pubmed: 22064851
Drug Metab Dispos. 2013 Dec;41(12):2187-96
pubmed: 24080162
Plast Reconstr Surg. 2009 Oct;124(4):1202-10
pubmed: 19935304
Pediatr Blood Cancer. 2008 Apr;50(4):769-71
pubmed: 18085684
Pharmacogenomics J. 2018 Jan;18(1):187-195
pubmed: 27779249
Nucleic Acids Res. 2016 Jan 4;44(D1):D110-5
pubmed: 26531826
JAMA Oncol. 2017 Nov 1;3(11):1558-1562
pubmed: 28448657
Am J Cancer Res. 2016 Nov 01;6(11):2416-2430
pubmed: 27904761
Health (Irvine Calif). 2013 May;5(5A):
pubmed: 24224072
Pharmacogenomics. 2016 May;17(7):731-41
pubmed: 27180762
Leukemia. 2013 Apr;27(5):1000-8
pubmed: 23212154
Paediatr Drugs. 2016 Aug;18(4):251-60
pubmed: 27142473
Science. 2015 May 8;348(6235):648-60
pubmed: 25954001
Crit Rev Oncol Hematol. 1999 Feb;29(3):267-87
pubmed: 10226730
Drug Metab Rev. 2014 Aug;46(3):325-42
pubmed: 24670052
Clin Cancer Res. 2016 Oct 1;22(19):4890-4900
pubmed: 27143689
Pharmacogenet Genomics. 2016 Feb;26(2):100-2
pubmed: 26618658
Indian J Pediatr. 2010 Jan;77(1):97-100
pubmed: 19936661
World J Biol Chem. 2016 Feb 26;7(1):14-43
pubmed: 26981194
Brain. 2014 Feb;137(Pt 2):402-10
pubmed: 24369383
Nat Commun. 2018 May 8;9(1):1825
pubmed: 29739930
Clin Cancer Res. 2012 Sep 15;18(18):5099-109
pubmed: 22843789
CA Cancer J Clin. 2013 Nov-Dec;63(6):419-37
pubmed: 24590861
Pharmacogenet Genomics. 2012 Apr;22(4):285-9
pubmed: 22336958
Genome Biol. 2016 Jun 06;17(1):122
pubmed: 27268795
Crit Rev Oncol Hematol. 2017 Jun;114:114-130
pubmed: 28477739
Am J Hum Genet. 2016 Sep 1;99(3):753-761
pubmed: 27569547
Nat Rev Cancer. 2010 Mar;10(3):194-204
pubmed: 20147901
J Pediatr Hematol Oncol. 2012 Apr;34(3):239-41
pubmed: 22246157
J Peripher Nerv Syst. 2015 Mar;20(1):37-46
pubmed: 25977177
Clin Cancer Res. 2017 Jul 1;23(13):3325-3333
pubmed: 28039263
BMC Bioinformatics. 2010 May 28;11:288
pubmed: 20509871
Clin Pharmacol Ther. 2017 Mar;101(3):391-395
pubmed: 27618250
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
JAMA. 2015 Feb 24;313(8):815-23
pubmed: 25710658
Am J Hum Genet. 2012 Dec 7;91(6):1103-7
pubmed: 23141292
Pediatr Neurol. 1995 Nov;13(4):314-8
pubmed: 8771166
JAMA Oncol. 2017 Apr 1;3(4):524-548
pubmed: 27918777
Pharmacoepidemiol Drug Saf. 2009 Aug;18(8):713-21
pubmed: 19507171
Pharmacogenet Genomics. 2016 Feb;26(2):51-2
pubmed: 26704670