Metabolic aspects of neuronal degeneration: From a NAD
Axon
Axon degeneration
Metabolism
Neurodegeneration
Nicotinamide adenine dinucleotide
Journal
Neuroscience research
ISSN: 1872-8111
Titre abrégé: Neurosci Res
Pays: Ireland
ID NLM: 8500749
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
14
05
2018
revised:
21
06
2018
accepted:
22
06
2018
pubmed:
15
7
2018
medline:
5
4
2019
entrez:
15
7
2018
Statut:
ppublish
Résumé
Cellular metabolism maintains the life of cells, allowing energy production required for building cellular constituents and maintaining homeostasis under constantly changing external environments. Neuronal cells maintain their structure and function for the entire life of organisms and the loss of neurons, with limited neurogenesis in adults, directly causes loss of complexity in the neuronal networks. The nervous system organizes the neurons by placing cell bodies containing nuclei of similar types of neurons in discrete regions. Accordingly, axons must travel great distances to connect different types of neurons and peripheral organs. The enormous surface area of neurons makes them high-energy demanding to keep their membrane potential. Distal axon survival is dependent on axonal transport that is another energy demanding process. All of these factors make metabolic stress a potential risk factor for neuronal death and neuronal degeneration often associated with metabolic diseases. This review discusses recent findings on metabolic dysregulations under neuronal degeneration and pathways protecting neurons in these conditions.
Identifiants
pubmed: 30006197
pii: S0168-0102(18)30342-0
doi: 10.1016/j.neures.2018.07.001
pmc: PMC6674977
mid: NIHMS1533096
pii:
doi:
Substances chimiques
Nerve Tissue Proteins
0
NAD
0U46U6E8UK
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
9-20Subventions
Organisme : NINDS NIH HHS
ID : R01 NS087632
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG013730
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM103422
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG013730
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS065053
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.
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